The results of sensitivity test for four Proteus species were compared. P. mirabilis was, in general, more drug sensitive than the other species and P. rettgeri was the least sensitive. The conclusion was drawn that species identification of Proteus is essential in routine bacteriological diagnosis.

Penicillin-induced spheroplasts from Escherichia coli and Proteus vulgaris, which at neutral pH had little resistance to osmotic lysis, retained viability in media of low osmolality at pH 5.0 to 5.5. In the presence of 1,000 IU of penicillin per ml (pH 5.0) in liquid media, E. coli remained in rod form without conspicuous growth. On hypotonic agar media at pH 5.2 with 1,000 IU of penicillin per...

A molecular manipulation efforts were made at β carbon of α, β unsaturated site of nalidixic acid by Michael addition, in expectation to get newer chemimanipulated derivatives with potent/modified antimicrobial spectrum. At the ends of chemimanipulative work, totally 5 derivatives were synthesized and characterized by spectral data. All the derivatives were screened for its antibacterial activi...