recently, choudhury and metiya [fixed points of weak contractions in cone metric spaces, nonlinear analysis 72 (2010) 1589-1593] proved some fixed point theorems for weak contractions in cone metric spaces. weak contractions are generalizations of the banach's contraction mapping, which have been studied by several authors. in this paper, we introduce the notion of $f$-weak contractions and als...

Leach, R. M., D. W. Sheehan, V. P. Chacko, and J. T. Sylvester. Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L294–L304, 2000.—To assess effects of smooth muscle energy state and intracellular pH (pHi) on pulmonary arterial tone during hypoxia, we measured ATP, phosphocreatine, Pi, and pHi by 31...

Fluoxetine, a selective serotonin reuptake inhibitor anti-depressant, causes undesirable side effects, including diarrhea and constipation. This research investigated the direct effects of fluoxetine at 0.001, 0.01, 0.1, 1, 10, 100 µM on duodenal proximal colonic tissue contractions. The investigation aimed to determine related mechanisms using an isolated mouse intestine model. Our study showe...

To test whether there is a regional difference in the exercise pressor reflex within a given muscle, we investigated the relationship between the inflection points of cardiovascular responses and muscle oxygenation during exercise. Seven subjects performed incremental exercise, which consisted of incremental 30-s static knee extensions, each separated by 30 s of recovery. The workload started a...

BACKGROUND Patients with celiac disease who present with symptoms of gastrointestinal hypomotility have abnormal antroduodenal manometry. There are no data on antroduodenal manometry in malabsorption syndrome (MAS) due to causes other than celiac disease. METHODS Fasting, post-prandial and post-octreotide antroduodenal motility parameters were compared in 18 untreated patients with MAS presen...

To examine the relations between erythrocyte sodium-lithium countertransport and renal proximal tubular sodium handling, we measured countertransport, and then subjected 30 normal and 32 hypertensive subjects, both white and black, to provocative maneuvers of volume expansion and contraction. The fractional excretions of sodium and lithium were measured simultaneously. In agreement with previou...

Lee, Wing-Kee, Malte Spielmann, Ulrich Bork, and Frank Thévenod. Cd -induced swelling-contraction dynamics in isolated kidney cortex mitochondria: role of Ca uniporter, K cycling, and protonmotive force. Am J Physiol Cell Physiol 289: C656–C664, 2005. First published April 20, 2005; doi:10.1152/ajpcell.00049.2005.—The nephrotoxic metal Cd causes mitochondrial damage and apoptosis of kidney prox...

[Purpose] The purpose of this study was to measure the muscle activities of the trunk muscles and upper limb muscles during maximum isometric contraction when temporomandibular joint alignment was achieved with a mandibular orthopedic repositioning appliance in order provide basic data on the effects of mandibular orthopedic repositioning appliance on the entire body. [Subjects] The present stu...

BACKGROUND Eccentric contractions induce muscle fiber damage that is associated with a decreased capacity to generate voluntary force and increased fiber membrane permeability. Changes in fiber membrane permeability results in cell depolarization that is expected to have an effect on the action potential propagation velocity of the muscle fibers. PURPOSE The aim of the study was to investigat...

Exaggerated contraction of airway smooth muscle is the major cause of symptoms in asthma, but the mechanisms that prevent exaggerated contraction are incompletely understood. Here, we showed that integrin α9β1 on airway smooth muscle localizes the polyamine catabolizing enzyme spermidine/spermine N1-acetyltransferase (SSAT) in close proximity to the lipid kinase PIP5K1γ. As PIP5K1γ is the major...