The precipitation recycling rate (PRR) is an important index when trying to understand the physical mechanisms behind effects of different sources water vapor on regional precipitation. We studied change in PRR mid- and lower reaches Yangtze River (MLRYR), correlation between external source local evaporation, possible reasons for interannual variation PRR. Our study was based evaluation model ...

Similar to mammals, several viral-sensing pattern recognition receptors (PRR) have been identified in birds including Toll-like receptors (TLR) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLR). Avian TLR are slightly different from their mammalian counterparts, including the pseudogene TLR8, the absence of TLR9, and the presence of TLR1La, TLR1Lb, TLR15, and TLR21. Avian TLR3 and...

OBJECTIVES To examine the relationships between physical function and gender-stereotyped traits and whether these relationships are modified by sex or social context. METHODS A total of 1995 community-dwelling older adults from the International Mobility in Aging Study (IMIAS) aged 65 to 74 years were recruited in Natal (Brazil), Manizales (Colombia), Tirana (Albania), Kingston (Ontario, Cana...

OBJECTIVE The comparative crude death rates (CDR) among non-vitamin K antagonist oral anticoagulants (NOACs) are unknown. Further, whether NOACs improve survival when compared with warfarin is also unclear. We compared CDR co-reported for four NOACs combined or separately versus warfarin within the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. METHODS ...

The spiking activity in the parietal reach region (PRR) represents the spatial goal of an impending reach when the reach is directed toward or away from a visual object. The local field potentials (LFPs) in this region also represent the reach goal when the reach is directed to a visual object. Thus PRR is a candidate area for reading out a patient's intended reach goals for neural prosthetic a...

AIM We have recently identified and characterized cancer stem cell (CSC) subpopulations within moderately differentiated buccal mucosal squamous cell carcinoma (MDBMSCC). We hypothesized that these CSCs express components of the renin-angiotensin system (RAS). METHODS 3,3'-Diaminobenzidine (DAB) immunohistochemical (IHC) staining was performed on formalin-fixed paraffin-embedded MDBMSCC sampl...

The pulmonary reimplantation response (PRR) is a form of membrane permeability pulmonary edema occurring in lung transplants. The severity of the PRR reflects the quality and duration of lung graft preservation. Free radicals formed during ischemia with reperfusion in the autotransplanted dog lung may play a role in producing PRR. We hypothesized that the addition of reduced glutathione (GSH) t...

BACKGROUND The currently recommended treatment algorithm for patients with advanced renal cell carcinoma who fail the first-line targeted therapy does not normally include pazopanib as a second-line treatment option. It would therefore be of interest to determine the efficiency of pazopanib in this setting in terms of the partial response rate (PRR), disease control rate (DCR), and progression-...

Background: Recent interest in drug development for hidradenitis suppurativa(HS) and atopic dermatitis(AD) has spurred dozens of clinical trials, some which have failed. One commonly cited reason trial failure is a high placebo response rate (PRR), yet little research exists into whether this difference exists. Methods: To minimize publication bias, we compiled list Phase 2/3 trials HS AD from ...

Many DNA lesions cause pausing of replication forks at lesion sites thus generating gaps in the daughter-strands that are filled-in by post replication repair (PRR) pathways. In S. cerevisiae, PRR involves Translesion Synthesis (TLS) mediated by Polη or Polζ, or Rad5-dependent gap-filling via a poorly characterized error-free mechanism. We have developed an assay to monitor error-free and mutag...