INTRODUCTION — Clostridium difficile associated disease (CDAD) is one of the most common hospitalacquired (nosocomial) infections, and is an increasingly frequent cause of morbidity and mortality among elderly hospitalized patients. C. difficile colonizes the human intestinal tract after the normal gut flora has been altered by antibiotic therapy and is the causative organism of antibiotic-asso...

1607 Over the ensuing seven months she had three more clinical relapses, each accompanied by reappearance in the stools of either the organism or its cytotoxin, or both. Each improvement after vancomycin (eight to 14-day-courses) was accompanied by disappearance of the organism. At one point she was given cholestyramine, but she was unable to tolerate it. Her illness was punctuated by malnutrit...

This paper provides a review of the largest studies (over period 2017 to 2022) on cost-effectiveness analysis recommended treatment algorithms for Clostridioides difficile infection in patients with antibiotic-associated diarrhea (AAD), including pseudomembranous colitis. The showed that professional medical societies Russia, EU and US as well meta-analyses consistently consider vancomycin most...

1.1 Condition: Clostridium difficile infection (CDI). A diagnosis of CDI implies: a) laboratory detection of C. difficile toxins and/or toxigenic C. difficile in faeces, rectal swab or bowel contents PLUS b) relevant clinical manifestations: diarrhoea (usually defined as 3 or more loose stools in a 24 hour period) or, less commonly, ileus, toxic megacolon or pseudomembranous colitis (identified...

Rectal biopsies from five patients with clindamycin-associated colitis were studied with the intention of identifying fibrin thrombi in capillaries. Capillary thrombosis was present in all five cases, three with pseudomembranous colitis and two with non-specific colitis. The significance of capillary thrombosis and its relationship to other ischaemic lesions of the gut are discussed.

CASE PRESENTATIONS Case 1 . A 62-year-old woman with diabetes was admitted because of an infected toe. Physical examination was normal except for an ulceration of the left 4th toe. Routine laboratory studies revealed only elevated blood sugar and moderate ketonuria. A roentgenogram of the toe revealed osteomyelitis. The infection improved with clindamycin therapy (300 mg IV, t:d), and the toe w...