BACKGROUND We hypothesized that gene transfer of vascular endothelial growth factor (VEGF) mediated by an adenovirus vector might induce pulmonary artery angiogenesis in a lamb model of pulmonary artery hypoplasia. METHODS Thirteen fetal lambs had left pulmonary artery banding at 106 days of gestation. Following birth, 3 groups were divided: VEGF group (n = 5) and beta-GAL group (n = 4) recei...

Complete septation of a double inlet left ventricle with left anterior subaortic outlet chamber was carried out successfully as a staged procedure during the first two years of life in a patient with severe pulmonary hypertension and an abnormal left atrioventricular valve. In contrast with isolated pulmonary artery banding, which rarely has led to a satisfactory septation or modified Fontan op...

or complicated ventricular septal defects. The main indication for the procedure was intractable congestive cardiac failure not responding to medical therapy. There was a I2 per cent mortality. Complications resulting from the operation are recorded. Twenty of these children have subsequently undergone repair of the ventricular septal defect and reconstruction of the pulmonary artery with a mor...

Background In the current surgical era PA banding is not indicated as palliation or stage procedure for patients with large VSD and severe PAH. We have reviewed our institutions experience in patients undergoing VSD repair with previously failed PA banding. Failure of PA banding was defined as pulmonary to aortic systolic pressure ratio (PASPR) > 0.8 in period of at least 6 months after palliat...

A histologic study was performed on 22 specimens of pulmonary atresia with ventricular septal defect to 1) ascertain the existence of the main pulmonary artery; 2) distinguish the ductus arteriosus from the systemic collateral arteries (SCA); 3) establish the nutritive or functional nature of collateral circulation; and 4) evaluate the morphology of the distal pulmonary bed. Three cases had abs...

In this work, Corno (1) presents long-term outcomes in a small group of patients with multiple ventricular septal defects treated with adjustable pulmonary artery banding (PAB). The results were satisfactory, with few complications. Despite recent progress in pediatric cardiac surgery, surgical management of very small babies with true Swiss cheese septum and cardiac failure is still challengin...

OBJECTIVES This retrospective study evaluated the feasibility and related outcome of intraluminal pulmonary artery banding (I-PAB). METHODS Thirty-two children underwent I-PAB between July 2006 and April 2014. The median age and weight were 60 days (range: 5 days to 4.2 years) and 3.7 kg (range: 2.6-13.0 kg), respectively. Cardiac diagnoses included single ventricle morphology (n = 11), compl...