نتایج جستجو برای: pulsatile

تعداد نتایج: 6163  

Journal: :Circulation research 1984
S Mifflin D Kunze

An in vitro preparation was used to examine the discharge of low pressure receptors in response to a pulsatile pressure stimulus. Both slowly adapting and rapidly adapting receptors were examined. After an increase in the mean level and/or dP/dt of a pulsatile pressure input, the discharge of slowly adapting receptors reached a steady state level within 2 minutes. An increase in mean pressure, ...

2011
Amit Bhat KPR Chowdary Lakshmi Narasu

Clinical studies have shown that circadian patterns influence the pharmacokinetics of certain drugs used in the treatment of different diseases. For such drugs, the bioavailability is influenced by the time of administration. The objective of this study was to investigate differences in the pharmacokinetic patterns between a pulsatile drug delivery system using a pulsatile capsule, pure active ...

Journal: :The Journal of clinical endocrinology and metabolism 1999
S B Seminara J C Achermann M Genel J L Jameson W F Crowley

X-linked adrenal hypoplasia congenita (AHC) is a disorder associated with primary adrenal insufficiency and hypogonadotropic hypogonadism (HH). The gene responsible for X-linked AHC, DAX1, encodes a member of the nuclear hormone receptor superfamily. We studied an extended kindred with AHC and HH in which two males (the proband and his nephew) were affected with a nucleotide deletion (501delA)....

Journal: :Chemical & pharmaceutical bulletin 2008
Hiroyuki Maeda Yutaka Ogawa Masato Ishiyama Tomoaki Hirayama Katsuhide Terada

The purpose of this study was to obtain a nicorandil pulsatile release tablet that has a well-regulated release lag time. When nicorandil is used as an antiangina drug, administration time control is important. A pulsatile release tablet is one of the effective approaches to modified release to reduce daily administration frequency. In this study, a pulsatile release tablet of nicorandil was fo...

Journal: :American journal of physiology. Endocrinology and metabolism 2002
Guang-Liang Jiang Charles R White Hazel Y Stevens John A Frangos

Bone cells are subject to interstitial fluid flow (IFF) driven by venous pressure and mechanical loading. Rapid dynamic changes in mechanical loading cause transient gradients in IFF. The effects of pulsatile flow (temporal gradients in fluid shear) on rat UMR106 cells and rat primary osteoblastic cells were studied. Pulsatile flow induced a 95% increase in S-phase UMR106 cells compared with st...

2011
Julia Mikhal Bernard J. Geurts

We present an immersed boundary method based on volume penalization, with which pulsatile flow in a model cerebral aneurysm is simulated. The model aneurysm consists of a curved vessel merged with a spherical cavity. The dominant vortical structures arising in the time-dependent flow are discussed and the evolution of the maximal shear stress in the aneurysm is analyzed. We approximate flow pro...

Journal: :Computer methods in biomechanics and biomedical engineering 2010
M Mamun Molla Manosh C Paul Giles Roditi

Transition of additive and non-additive pulsatile flows through a simple 3D model of arterial stenosis is investigated by using a large eddy simulation (LES) technique. We find in both the pulsatile cases that the interaction of the two shear layers, one of which separates from the nose of the stenosis and the another one from its opposite wall, causes recirculation in the flow downstream of th...

Journal: :Journal of applied physiology 2002
Robert G Presson William A Baumgartner Amanda J Peterson Robb W Glenny Wiltz W Wagner

Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained d...

Journal: :IEEE robotics and automation letters 2021

Pulsatile flow is widespread in nature, but replicating such impulsive periodic pumping routines with traditional rotary actuators complex and energetically inefficient. We demonstrate the feasibility of an actuator capable generating displacement by exploiting bistable equilibrium a simple mechanism. These kind mechanisms, commonly known as snap-through offer benefit sudden release elastic ene...

Journal: :Circulation research 1989
M W Chapleau F M Abboud

The threshold pressure of single baroreceptor units is decreased after compared with before exposure to pulsatile pressure according to previous studies in our laboratory. The purpose of the present study is to characterize the determinants of sensitization of arterial baroreceptors by pulsatile pressure. Carotid sinus nerve activity was recorded in dogs anesthetized with chloralose. Two indexe...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید