Objective: The purpose of this retrospective study is to review our experience with tacrolimus as a rescue immunosuppressant for heart transplant recipients with refractory rejection or cyclosporine intolerance. Methods: From June 1995 to November 1998, 15 cardiac transplant recipients were converted from our standard cyclosporine-based immunosuppressive regimen to a tacrolimus-based treatment....

This paper deals with quality assurance procedures for general-purpose language resources. Special attention is paid to quality control in wordnet development. General issues of quality management are tackled; technical as well as methodological aspects are discussed. As a case study, the application of the described procedures is demonstrated on the quality evaluation techniques in the context...

Sense of purpose is seen as a catalyst for successful ageing, predicting wide range health outcomes and mortality. However, its role in fostering subjective well-being during old age has received less attention, especially the bidirectional nature this relationship. The present study examined how sense predicts predicted by life stage. Panel data from Health Retirement Study ( N = 8980) were us...