Polymyxin B (PX) forms complexes with the O-antigenic lipopolysaccharide (LPS) of Salmo­ nella typhimurium which are stable in aqueous 0.14 M sodium chloride at neutral pH. PX can be quantitatively recovered from the complex by changing the pH from 7 to 1, or by treatment with the cationic detergent cetylpyridinium chloride. This proves that complex formation does not involve covalent linkages,...

To investigate the influence of the pineal gland through melatonin secretion on the physiological and morphological parameters of pancreatic islets, we studied the plasma biochemistry and morphological and morphometric characteristics of the endocrine pancreas of male Wistar rats. The animals were distributed into five groups of ten rats each: NC - normal control group; NS -- sham-operated grou...

Inflammasome plays a critical role in psoriasis. Therefore, targeting NLRP3 inflammasome may be useful strategy to treat In this study, we found that 1-methylpropyl 2-imidazolyl disulfide (PX-12) had potential inhibitory effects on imiquimod (IMQ)-induced IL-1β and IL-18 secretion as well pyroptotic cell death lipopolysaccharide (LPS)-primed THP-1 macrophages. PX-12 also inhibited the release o...

We propose a novel approach in the assessment of random risk variable X by introducing magnitude-propensity measures (mX, pX). This bivariate measure intends to account for dual aspect risk, where magnitudes x tell how high are losses incurred, whereas probabilities P(X = x) reveal often one has expect suffer such losses. The basic idea is simultaneously quantify both severity mX and propensity...

Islet beta-cells are the regulatory element of the glucose homeostasis system. When functioning normally, they precisely counterbalance changes in insulin sensitivity or beta-cell mass to preserve normoglycemia. This understanding seems counter to the dogma that beta-cells are regulated by glycemia. We studied 60% pancreatectomy rats (Px) 4 wk postsurgery to elucidate the beta-cell adaptive mec...

African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation defect whereas parasites that lack the cytosolic Px I and Px II undergo extremely fast lipid peroxi...

Abstract Land surface processes are vital to the performance of regional climate models in dynamic downscaling application. In this study, we investigate sensitivity simulation by using weather research and forecasting (WRF) model at 10-km resolution land schemes over Central Asia. The WRF was run for 19 summers from 2000 2018 configured with four different including CLM4, Noah-MP, Pleim-Xiu SS...

BACKGROUND Due to problems with chemical control, there is increasing interest in the use of microsporidia for control of lepidopteran pests. However, there have been few studies to evaluate the susceptibility of exotic species to microsporidia from indigenous Lepidoptera. METHODOLOGY/PRINCIPAL FINDINGS We investigated some biological characteristics of the microsporidian parasite isolated fr...