In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhib...

Herein, we report an efficient method for synthesis of novel selenocyanates amino pyrazole, uracil, and isoxazole derivatives using in situ triselenium dicyanide from the combination malononitrile selenium dioxide DMSO medium. Using same but changing stoichiometry reagents sequence addition temperature, symmetrical selenoethers pyrazoles uracils were prepared good yields. Furthermore, utilized ...

Cu salts have been found to promote the cycloaddition reaction of sydnones and terminal alkynes, providing significant reduction in reaction times. Specifically, the use of Cu(OTf)2 is found to provide 1,3-disubstituted pyrazoles, whereas simply switching the promoter system to Cu(OAc)2 allows the corresponding 1,4-isomers to be produced. The mechanism of the Cu-effect in each case has been inv...

As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as inhibitors of Mycobacterium tuberculosis (MTB), which is the causative agent of tuberculosis. One of these compounds showed high activity against MTB (M...

An efficient and green protocol for the synthesis of pyrazoles derivatives by one-pot reaction of different 1,3-dicarbonyl compounds with hydrazines/hydrazides has been developed using nano-sulfated zirconia, nano-structured ZnO, nano-g-alumina and nano-ZSM-5 zeolites, as the catalyst. The optical properties of the nano-structured catalysts and organic molecules were studied. The advantages of ...