نتایج جستجو برای: pyrin
تعداد نتایج: 772 فیلتر نتایج به سال:
The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases. However, evidence from an autoinflammatory murine model indicates that IL-18, the other cytokine triggered by inflammasome activity, is important in its own...
The B30.2/SPRY domain is present in approximately 700 eukaryotic (approximately 150 human) proteins, including medically important proteins such as TRIM5alpha and Pyrin. Nonetheless, the functional role of this modular domain remained unclear. Here, we report the crystal structure of an SPRY-SOCS box family protein GUSTAVUS in complex with Elongins B and C, revealing a highly distorted two-laye...
Gain-of-function mutations that activate the innate immune system can cause systemic autoinflammatory diseases associated with increased IL-1β production. This cytokine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome; however, IL-18 has not yet been specifically implicated in the pathogenesis of hereditary autoinflammatory disorders. We have now i...
2-(10-Pyrenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (PyrNN) and 2-(10-pyrenyl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-1-oxyl (PyrIN) form pentacoordinate metal–radical complexes with Cu(hfac)2: [Cu(hfac)2PyrNN] and [Cu(hfac)2PyrIN], 1 and 2, respectively. In 1, one aminoxyl unit of PyrNN coordinates to Cu(II) in a distorted square pyramidal environment. In 2, an unu...
The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic ...
Pyrin lähestymään artikkelissani Georges Didi-Hubermanin materiaalisuuksia koskevaa ajattelua ottaen lähtökohdaksi Immanuel Kantin esikriittisen negatiivisia suureita koskevan tutkielman (1783) sekä Gilles Deleuzen teokset Bergsonisme (1966), Différence et répétition (1968) ja Le Pli. Leibniz le baroque (1988). Viittaan myös Maurice Merleau-Pontyn Visible l'invisible -teoksessaan (1964) esittäm...
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