background :co-morbid psychiatric disorders affect prognosis, psychosocial adjustment and post-surgery satisfaction in patients with gender identity disorder. in this paper, we assessed the frequency of personality disorders in iranian gid patients.   methods : seventy- three patients requesting sex reassignment surgery (srs) were recruited for this cross- sectional study. of the participants, ...

background :5httlpr polymorphism (5- hydroxytryptamine transporter linked promoter region polymorphism) is the most widely studied genetic variant in psychiatry. the present study is a modest effort at ascertaining the role of 5ht transporter linked promoter region polymorphism (5httlpr) in anxiety and depressive disorders in kashmir (india).the aim of this study was to examine 5-hydroxy trypta...

objective in this article, a motor skill disorder called developmental coordination disorder (dcd), that is usually first diagnosed during childhood, is explained and discussed. in the year 1987, dcd was formally recognized as a distinct disorder in children by the american psychiatric association  (apa). dcd is a generalized term for the children who have some degrees of impairment in the deve...

The interaction of 2-ethoxymethylidene-3-oxo esters and their analogues with 5-aminotetrazole is an efficient synthetic approach to novel azaheterocycles. 2-Ethoxymethylidene-3-oxo esters bearing alkyl substituents react with 5-aminotetrazole to form ethyl 2-azido-4-alkylpyrimidine-5-carboxylates which are capable of subsequent nucleophilic substitution. The use of diethyl 2-ethoxymethylidenema...

The mean (N-O) bond dissociation enthalpies were derived for three 2-methyl-3-(R)-quinoxaline 1,4-dioxide (1) derivatives, with R = methyl (1a), ethoxycarbonyl (1b), and benzyl (1c). The standard molar enthalpies of formation in the gaseous state at T = 298.15 K for the three 1 derivatives were determined from the enthalpies of combustion of the crystalline solids and their enthalpies of sublim...

in which the migrating group X can be OH, NH2 or a suitable substituted carbon atom such as C (=C H 2)C 02H. This paper discusses evidence for the participation of organic radicals as intermediates in these reactions. Theoretical and model studies supporting the intermediacy of radicals in the reactions catalysed by the enzymes diol dehydratase and a-methyleneglutarate mutase are described. For...

Synthesis, purification and characterization of [4-ethoxycarbonyl-40-carboxy-2,20-bipyridine]bis(2,20-bipyridine) ruthenium(II) hexafluorophosphate is described. This complex is shown to be electrochemiluminescent in aqueous solution during cathodic pulse polarization of thin insulating film-coated electrodes. Electrochemiluminescence (ECL) lifetime of the complex was observed to be ca. 40 ms a...

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for a carboxy, cyano or amide group, or introducing substituents in the phenyl ring of the ester and...

The altered amino acid (AA) levels as neurotransmitter closely correlate to neurodegenerative conditions including Alzheimer's disease (AD). Target profiling analysis of nineteen AAs in brain cortex samples from three Tg2576 mice as AD model and three littermate mice as control model was achieved as their N(O,S)-ethoxycarbonyl/tert-butyldimethylsilyl derivatives by gas chromatography. Subsequen...