Objectives. TEACH (NCT00896051) was a randomized, open-label, two-arm Phase II trial to investigate the pharmacokinetic interaction between etravirine and atazanavir/ritonavir and safety and efficacy in treatment-experienced, HIV-1-infected patients. Methods. After a two-week lead-in of two nucleoside reverse transcriptase inhibitors (NRTIs) and atazanavir/ritonavir 300/100 mg, 44 patients rece...

BACKGROUND This randomised, double-blind, four-way, crossover, Phase II study compared the 24-h forced expiratory volume in 1 s (FEV1) profile of alternative dosing frequencies of two total daily doses of olodaterol (5 and 10 μg) in patients with chronic obstructive pulmonary disease (COPD). METHODS Patients received olodaterol 2 μg twice daily (BID), 5 μg BID, 5 μg once daily (QD) and 10 μg ...

We aim to study the scaling behaviors of important correlation measures including entanglement entropy and the newly proposed measure of purely quantum correlations, quantum discord (QD), which quantifies all nonclassical correlations including entanglement as a subset, in general quantum spin systems. In this work we emphasize on the latter measure (QD) and present the explicit derivation of t...

Nanocrystal quantum dots (QD) show great promise toward improving solar cell efficiencies through the use of quantum confinement to tune absorbance across the solar spectrum and enable multi-exciton generation. Despite this remarkable potential for high photocurrent generation, the achievable open-circuit voltage (Voc) is fundamentally limited due to non-radiative recombination processes in QD ...

Time-gated Förster resonance energy transfer (FRET) using the unique material combination of long-lifetime terbium complexes (Tb) and semiconductor quantum dots (QDs) provides many advantages for highly sensitive and multiplexed biosensing. Although time-gated detection can efficiently suppress sample autofluorescence and background fluorescence from directly excited FRET acceptors, Tb-to-QD FR...

(2013) Robust, specific ratiometric biosensing using a copper-free clicked quantum dot-DNA aptamer sensor. 5 We report herein the successful preparation of a compact, functional CdSe/ZnS core/shell quantum dot (QD)-DNA conjugate via the highly efficient copper-free " click chemistry " (CFCC) between a dihydro-lipoic acid-polyethylene glycol-azide (DHLA-PEG-N 3) capped QD and a cyclooctyne modif...

The first generation of luminescent semiconductor quantum dot (QD)-based hybrid inorganic biomaterials and sensors is now being developed. It is crucial to understand how bioreceptors, especially proteins, interact with these inorganic nanomaterials. As a model system for study, we use Rhodamine red-labeled engineered variants of Escherichia coli maltose-binding protein (MBP) coordinated to the...

We present an experimental study of a large quantum dot QD capacitively coupled to an aluminum single electron transistor SET and irradiated with terahertz radiation from a blackbody source. The SET is used as a noninvasive electrometer sensitive to a single-charge fluctuation on the QD. Qualitatively different regimes of QD confinement have been identified from the SET response. We demonstrate...

Investigation of many cellular processes using fluorescent quantum dots (QDs) is hindered by the nontrivial requirements for QD surface functionalization and targeting. To address these challenges, we designed, characterized and applied QD-trisNTA, which integrates tris-nitrilotriacetic acid, a small and high-affinity recognition unit for the ubiquitous polyhistidine protein tag. Using QD-trisN...

The conjugation of biomolecules such as proteins and peptides to semiconductor quantum dots (QD) is a critical step in the development of QD-based imaging probes and nanocarriers. Such protein-QD assemblies can have a wide range of biological applications including in vitro protein assays and live-cell fluorescence imaging. One conjugation scheme that has a number of advantages is the self-asse...