BACKGROUND The objective of the study was to analyse whether azacitidine is a cost-effective option for the treatment of myelodysplastic syndrome in the Spanish setting compared with conventional care regimens, including best supportive care, low dose chemotherapy and standard dose chemotherapy. METHODS A life-time Markov model was constructed to evaluate the cost-effectiveness of azacitidine...

BACKGROUND Radiofrequency catheter ablation (RFA) has emerged as an important treatment strategy for atrial fibrillation (AF). The potential cost-effectiveness of RFA for AF, relative to antiarrhythmic drug (AAD) therapy, has not been fully explored from a US perspective. METHODS AND RESULTS We constructed a Markov disease simulation model for a hypothetical cohort of patients with drug-refra...

OBJECTIVE To determine whether the risk of falling (with a possible increased chance of subdural hematoma) should influence the choice of antithrombotic therapy in elderly patients with atrial fibrillation. DESIGN A Markov decision analytic model was used to determine the preferred treatment strategy (no antithrombotic therapy, long-term aspirin use, or long-term warfarin use) for patients wi...

mapping a certain disease into a system of disabling attributes allows researchers to compare diseases within a common framework. to quantify the total burden of morbidity (e.g., morbidity attributable to alcohol use), so-called disability weights (DWs) must be generated. general-population surveys can be used to derive DWs from health valuation tasks. this article describes the application of ...

aspirin is one of the certified medicines commonly used for the secondary prevention of myocardial infarction (mi). aspirin side effects and gastrointestinal bleeding, in particular, have arisen debates on its use for the primary prevention of mi. the present research evaluates the cost-effectiveness of the use of aspirin in the primary prevention of mi among iranian men with average cardiovasc...