we used qcd factorization for the hadronic matrix elements to show that the existing data, in particular the branching ratios br ( ?j/?k) and br ( ?j/??), can be accounted for this approach. we analyzed the decay within the framework of qcd factorization. we have complete calculation of the relevant hard-scattering kernels for twist-2 and twist-3. we calculated this decays in a special scale ( ...

INTRODUCTION Anti-diabetes medication regimen adherence is a clinical challenge in elderly patients with type 2 diabetes (T2D) and other comorbidities associated with aging. Glucagon-like peptide-1 receptor agonists (GLP-1RA) therapies such as exenatide once weekly (QW), exenatide twice daily (BID), and liraglutide once daily (QD) are an increasingly used class of drugs with proven efficacy and...

OBJECTIVE Early treatment following a first clinical demyelinating event (FCDE) delays further disease activity in patients with multiple sclerosis (MS). This study determined the effects of early versus delayed treatment (DT) with subcutaneous interferon (sc IFN) β-1a 44 μg in patients with an FCDE up to 60 months postrandomisation. METHODS Patients who completed the 24-month double-blind RE...

PURPOSE To determine the maximum tolerated dose (MTD), safety, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary antitumor activity of CT-322 (BMS-844203), a VEGFR-2 inhibitor and the first human fibronectin domain-based targeted biologic (Adnectin) to enter clinical studies. EXPERIMENTAL DESIGN Patients with advanced solid malignancies were treated with escalating doses of ...

Sympathetic nerve activity (SNA) in neurons projecting to skeletal muscle blood vessels increases during rapid-eye-movement (REM) sleep, substantially exceeding SNA of non-REM (NREM) sleep and quiet wakefulness (QW). Similar SNA increases to cerebral blood vessels may regulate the cerebral circulation in REM sleep, but this is unknown. We hypothesized that cerebral SNA increases during phasic R...

In this work, optical properties of semiconductor quantum wells (QW) are investigated, which are relevant for the light pattern (speckle pattern) emitted in nonspecular directions by QW after resonant excitation of the exciton states. This secondary emission (SE) contains information on disorder and scattering processes in the sample. In particular, three main topics are investigated along this...

BACKGROUND Long-term treatment is necessary to slow the progression of type 2 diabetes (T2D). Here, we examined the safety and efficacy of 6 years of treatment with exenatide once weekly (QW) among patients with T2D in the DURATION-1 trial. METHODS The study enrolled patients aged ≥16 years with T2D treated primarily with metformin and sulfonylureas. Following 30 weeks of randomized treatment...

Apollonian circle packings arise by repeatedly filling the interstices between four mutually tangent circles with further tangent circles. We observe that there exist Apollonian packings which have strong integrality properties, in which all circles in the packing have integer curvatures and rational centers such that (curvature)×(center) is an integer vector. This series of papers explain such...

In this work, InGaN/GaN light-emitting diodes (LEDs) possessing varied quantum well (QW) numbers were systematically investigated both numerically and experimentally. The numerical computations show that with the increased QW number, a reduced electron leakage can be achieved and hence the efficiency droop can be reduced when a constant Shockley-Read-Hall (SRH) nonradiative recombination lifeti...

We present a detailed examination of a multiple InxGa1-xN quantum well (QW) structure for optoelectronic applications. The characterization is carried out using scanning transmission electron microscopy (STEM), combining high-angle annular dark field (HAADF) imaging and electron energy loss spectroscopy (EELS). Fluctuations in the QW thickness and composition are observed in atomic resolution i...