The epidemiology of Rhodococcus equi foal pneumonia is changing and remains ill-defined. Few foal-specific or farm-specific factors have been correlated with occurrence of this disease. The density of mares and foals and the airborne concentration of virulent isolates of R. equi are associated with the disease, but a causal relationship has not been established for either factor. Author’s addre...

Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in foals but does not induce disease in adult horses. Virulence of R. equi depends on the presence of a large plasmid, which encodes a family of seven virulence-associated proteins (VapA and VapC to VapH). Eradication of R. equi from the lungs depends on gamma interferon (IFN-gamma) production by T lymphocytes. The o...

BACKGROUND Macrolide-resistant isolates of Rhodococcus equi are emerging, prompting the search for clinically effective alternative antimicrobials. HYPOTHESIS The proportion of foals with ultrasonographic evidence of pneumonia presumed to be caused by R. equi that had a successful outcome when administered gallium maltolate (GaM) PO would not be more than 10% inferior (ie, lower) than that of...

Rhodococcus equi is a facultative intracellular bacterium that can escape from bactericidal mechanisms associated with phagocytosis. Virulence-associated protein A (VapA), encoded on a virulence-associated plasmid, is essential for intracellular survival in macrophages, but its function is not known. Here, we show that the extracellular addition of recombinant glutathione S-transferase (GST)-Va...

Equine piroplasmosis is a tickborne disease of equids with worldwide distribution, caused by Theileria equi and Babesia caballi. The aim of this study was molecular detection of T. equi and B. caballi in donkeys in northeastern Iran and investigate the association between positivity of piroplasm infection and host-related factors. In the present study, Blood samples were collected from 106 appa...

We introduce the idea of an ‘‘equi-g(r) sequence.’’ This consists of a series of equilibrium many-body systems which have different number densities r but share, at a given temperature, the same form of pair correlation function, termed ‘‘target g(r).’’ Each system is defined by a pair potential indexed by r as in ur(r). It is shown that for such a sequence a terminal density r ! exists, beyond...

| Rhodococcus equi is a soil actinomycete responsible for severe respiratory disease in young foals leading to high mortality. The organism is also emerging as an important pathogen in immune-compromised humans. Intracellular localization of R. equi makes therapeutic management very difficult and prolonged lasting up to three months. Presently no suitable vaccine and effective serological test ...

equine piroplasmosis is a tickborne disease of equids with worldwide distribution, caused by theileria equi and babesia caballi. the aim of this study was molecular detection of t. equi and b. caballi in donkeys in northeastern iran and investigate the association between positivity of piroplasm infection and host-related factors. in the present study, blood samples were collected from 106 appa...

Rhodococcus equi (R. equi) is a microorganism that was first identified in horses. Afterward, it found to cause opportunistic infections immunosuppressed patients. It causes especially pulmonary immunocompromised patients while rarely diseases such as septic arthritis and soft tissue infections. important question epidemiological risk factors for the diagnosis of disease. Also, clinician-microb...