Hypertrophic scar (HS) is a serious skin fibrotic disease characterized by excessive hypercellularity and extracellular matrix (ECM) component deposition. Autophagy is a tightly regulated physiological process essential for cellular maintenance, differentiation, development and homeostasis. However, during the formation of HS, whether and how autophagy is regulated in dermal fibroblasts are sti...

1. Bone formation in the rabbit kidney with ligated vessels takes place (a) through the activity of young fibroblasts which accumulate to form a membrane-like structure; (b) subsequently by direct ossification of hyaline connective tissue in continuity with preformed bone; and (c) through erosion of lime placques by granulating tissue and laying down of lamellar bone by cells derived from fibro...

BACKGROUND Soft tissue injury imposes major public health burdens worldwide. The positive effect of China's Tibetan medicine and the Lamiophlomis rotata-based herbal Pain Relieving Plaster (PRP) on healing closed soft tissue injury (CSTI) has been reported. The herbs contained in Plaster are also referred as 'blood-activating and stasis-dispelling' in herbal medicine. The formula of the plaster...

Many of our ideas about cellular memory of fate and position come from regeneration studies in salamanders. A popular notion is that cells of the blastema transdifferentiate to different fates during limb regeneration. In a recent issue of Nature, Tanaka and colleagues challenge this notion. Using transplant experiments with GFP-expressing axolotl, they show vividly which cells of the blastema ...

The purpose of this study was to evaluate the efficacy of a topical formulation containing imidacloprid and moxidectin for eradication of Psoroptes cuniculi in rabbits. Fourteen adult rabbits from a rabbit husbandry were enrolled in the study. Rabbits were treated with 40 mg imidacloprid and 4 mg moxidectin monthly as spot-on on Days 0, 30, and 60. No other treatment or environmental decontamin...

objective: to investigate the effect of intracerebroventricular injection of histamine on pain induced by subcutaneous iniection of formalin in the left ear of rabbit and the effect of the amine on morphine analgesia and naloxone hyperalgesia. design: experimental study. animals: sixty - six male new zealand white rabbits weighing 2.640.16kg. procedure: intracerebroventricular injections of the...

After limb amputation, urodele amphibians can regenerate lost parts perfectly throughout their life. However, Xenopus laevis shows its characteristic limb regenerative ability. Although Xenopus tadpole has the capacity to regenerate their limbs after amputation, after amputation of a froglet (a small frog after metamorphosis) limb, it can regenerate only a spike-shaped cartilage which has no pa...

The regenerating mouse digit tip is a unique model for investigating blastema formation and epimorphic regeneration in mammals. The blastema is characteristically avascular and we previously reported that blastema expression of a known anti-angiogenic factor gene, Pedf, correlated with a successful regenerative response (Yu, L., Han, M., Yan, M., Lee, E. C., Lee, J. & Muneoka, K. (2010). BMP si...

After limb amputation, urodele amphibians can regenerate lost parts perfectly throughout their life. However, Xenopus laevis shows its characteristic limb regenerative ability. Although Xenopus tadpole has the capacity to regenerate their limbs after amputation, after amputation of a froglet (a small frog after metamorphosis) limb, it can regenerate only a spike-shaped cartilage which has no pa...