OBJECTIVES To determine whether poly (ADP-ribose) polymerase-1/2 (PARP-1/2) inhibition enhances radiation-induced cytotoxicity of pancreatic adenocarcinoma in vitro and in vivo, and the mechanism by which this occurs. METHODS Pancreatic carcinoma cells were treated with ABT-888, radiation, or both. In vitro cell viability, apoptosis, and PARP activity were measured. Orthotopic xenografts were...

Background: Although ionizing radiation is widely used to diagnose many diseases, the relevant hazards are known to be as an important limitation of its application. It is believed that the awareness of ionizing radiation dose values is one of the main stages in patient's radiation protection. The purpose of this study has been to investigate the level of physicians' knowledge about radiation d...

Introduction: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. There is increasing evidence that combining radiation therapy with a radiosensitizer can enhance the efficiency of this treatment modality. A radiosensitizer preferably enhances dose at the site of tumor and increases discrimination between tumor and normal surrounding tissue...

Background: Gold nanoparticles (GNPs) are among the most promising radiosensitive materials in radiotherapy. Studying the effective sensitizing factors such as nanoparticle size, concentration, surface features, radiation energy and cell type can help to optimize the effect and possible clinical application of GNPs in radiation therapy. In this study, the radiation sensitive polymer gel was use...

PURPOSE Inhibition of checkpoint kinase 1 has been shown to enhance the cytotoxicity of DNA-damaging targeted chemotherapy through cell cycle checkpoint abrogation and impaired DNA damage repair. A novel checkpoint kinase 1/2 inhibitor, AZD7762, was evaluated for potential enhancement of radiosensitivity for human tumor cells in vitro and in vivo xenografts. EXPERIMENTAL DESIGN Survival of bo...

background: to enhance the dose to tumor, the use of high atomic number elements has been proposed. objective: the aim of this study is to investigate the effect of gold nanoparticle distribution on dose enhancement in tumor when the tumor is irradiated by typical monoenergetic x-ray beams by considering homogeneous and inhomogeneous distributions of gold nanoparticles (gnps) in the tumor. meth...

background: the aim of this study was to investigate clinical applications of mobile c-arms and consequent radiation risk,to increase medical attention on radiation protection, and to provide basic data for safe radiation use in the operating room. materials and methods: in this study, a total of 374 surgical operations, conducted using a portable fluoroscopic x-ray system from january to march...

The dentist considering adopting digital radiological technology should consider more than the type of detector with which to capture the image. He/she should also consider the mode of display, image enhancement, radiation dose reduction, how the image can be stored long term, and infection control.