At least two distinct mechanisms appear to be responsible for accumulation of iodine by the thyroid gland. The first, called the "iodide trap" by Vanderlaan and Vanderlaan (1), involves the concentration, presumably within the thyroid cells, of inorganic iodide obtained from the circulating blood. The second, called hormonal synthesis, involves the utilization of the trapped iodide for the synt...

Introduction: This is a prospective study of patients treated for a solitary toxic nodule with a fixed dose of radioiodine ( I) and followed for at least 1 year in Mashhad, north east of Iran. 131 Methods: We evaluated 780 patients who presented to the university hospital of Ghaem during a 7-year period because they had at least one thyroid nodule. We found hot thyroid nodules in 95 (12%) patie...

OBJECTIVE Radioiodine (131I) therapy is absolutely contraindicated in pregnancy yet reports of inadvertent exposure continue to appear in the literature. In this review, we discuss the risks of fetal exposure and prevention strategies in the light of current guidelines. METHODS We performed a literature search on MEDLINE using the terms radioiodine, I-131, toxicity, complications and pregnanc...

PURPOSE Human sodium/iodide symporter (hNIS) protein is a membrane glycoprotein that transports iodide ions into thyroid cells. The function of this membrane protein is closely regulated by post-translational glycosylation. In this study, we measured glycosylation-mediated changes in subcellular location of hNIS and its function of iodine uptake. METHODS HeLa cells were stably transfected wit...

INTRODUCTION Malignant struma ovarii is a rare ovarian neoplasm composed predominantly of mature thyroid tissue. CASE REPORT A right ovarian tumor was discovered at ultrasound examination in a 20-year-old woman. Complete right ovariectomy was done - histopathological examination revealed papillary thyroid carcinoma arising in struma ovarii (malignant struma ovarii). Patient underwent subseque...

Introduction: Nuclear accidents release large quantities of radioactive materials into the environment. Iodine-131 and cesium-137 are two radionuclides released during nuclear accident, which can pose the greatest cancer risks. These radionuclides can be moved to other areas through rain and wind. The aim of this study was to develop efficient and economical biological...

BACKGROUND Large multinodular goiter (MNG) in elderly people is a common finding which can require intervention. The long-term effect of radioiodine therapy on thyroid volume (TV) and function after recombinant human (rh) TSH pre-treatment was evaluated. METHODS After baseline evaluation, 40 subjects over 60 years old with a large MNG were treated with 131I up to the activity of 600 MBq. Nine...

UNLABELLED Radioactive iodine uptake (RAIU) is a test used to differentiate hyperthyroidism from thyroiditis and to calculate the radioiodine dose for treatment of Graves' disease. We aimed to evaluate the predictive role of 24h RAIU with respect to the outcome of radioiodine therapy in patients with diffuse toxic goiter (DTG). METHODS Case records of patients with DTG treated with radioactiv...