It has long been known that treatment with propylthiouracil and other antithyroid drugs inhibits organic binding of iodine and leads to a reduction in total iodine in the thyroid (1). The work of Franklin et al. (2-4) showed that these agents also prevent incorporation of radioiodine into organic compounds by thyroid slices in Z.&O. Pitt-Rivers (5), finding that acetyldiiodotyrosine did not for...

BACKGROUND AND AIM This study aimed at determining whether there is a risk regarding the development of second primary malignancies after patient exposure to the low and medium radioiodine activity used during the treatment of differentiated thyroid cancers (DTC). METHODS Second primary malignancies that occurred after DTC were detected in 1,990 patients treated between 1970 and 2003. The mea...

BACKGROUND Thyroid neoplasia is common in dogs, but there are few reports of dogs with ectopic, sublingual thyroid tumors. OBJECTIVES To describe clinical features and outcomes of dogs with ectopic, sublingual thyroid neoplasia. ANIMALS Five hundred and forty-four dogs with thyroid neoplasia. METHODS This retrospective study reviewed the medical records of dogs referred for thyroid neopla...

Oncolytic adenoviruses can be engineered for better tumor selectivity, gene delivery and be armed for imaging and concentrating radionuclides into tumors for synergistic oncolysis. We constructed Ad5/3-hTERT-hNIS where replication is controlled by hTERT-promoter. Ad5/3-hTERT-hNIS expresses hNIS for imaging of transgene expression and for treatment of infected tumors by radioiodine. Ad5/3-hTERT-...

UNLABELLED Radioiodine ((131)I) is a critical component in the treatment of differentiated thyroid cancer. We recently saw a patient with thyroid cancer who was hesitant to take (131)I treatment because he had previously encountered an allergic reaction to administration of iodine-containing radiocontrast agent for computed tomography (CT) scanning. We were able to administer (131)I treatment a...

radioiodine (1-131) is the treatment of choice in differentiated thyroid carcinoma. external radiotlierapy however, has it's own roie in these tumors. treatment of anaplastic thyroid carcinoma 1ms not acliieved any notahle success yet, though combined - modality regimens of radiotherapy and chemotherapy have sometimes shown significant results. in this paper the role of radiotlierapy and chemot...

OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an intended dose of 3.7 MBq/g thyroid tissue corrected to a 100% uptake of iodin...

Introduction: Retention of I-131 in the body of patients with differentiated thyroid carcinoma (DTC) has a direct effect on therapeutic outcome of radioiodine therapy. There are several factors that may influence retention time of radioiodine in the body of these patients. In this study we are going to assess effects of administered radioiodine activity, serum thyroid stimulati...