introduction one of the important applications of nuclear physics in medicine is the use of radioactive elements as radiopharmaceuticals. metastatic bone disease is the most common form of malignant bone tumors. samarium-153-ethylene diamine tetramethylene phosphonate (153sm-edtmp) as a radiopharmaceutical is used for pain palliation. this radiopharmaceutical usually emits beta particles, which...

This article reviews available radionuclide-based techniques for glomerular filtration rate (GFR) measurement, focusing on clinical indications for GFR measurement, ideal GFR radiopharmaceutical tracer properties, and the 2 most common tracers in clinical use. Methods for full, 1-compartment, and single-sample renal clearance characterization are discussed. GFR normalization and the role of GFR...

As a part of our ongoing research on synthesis of intracellular contrast agents, we have synthesized D-octaarginines, L-octaarginines and stearyloctaarginines covalently attached to the well established contrast agent (Gd-DTPA) and a fluorescent moiety, useful for MR imaging as well as optical imaging. 1 Max Planck Institute for Biological Cybernetics, Tübingen, Germany. 2 Radiopharmaceutical D...

At the present time three most common approaches are used for planning of radionuclide therapy: administration fixed activity in radiopharmaceutical, or normalized per unit body mass surface. That may lead to significant deviations between prescribed and real absorbed doses healthy organs tissues. These associated with differences biodistribution pharmacokinetics radiopharmaceutical models pati...

Abstract Objectives Radiopharmaceuticals, since the discovery of first medical application radioactive isotope, have been essential therapeutics for diagnosis and treatment numerous diseases. Since Directive 2001/83/EC entered in force, European regulatory authorities established a harmonised framework to set quality requirements industrial production radiopharmaceuticals. However, little is kn...

Intoduction: Therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. Among some therapeutic radiopharmaceuticals, Ho-1,4,7,10 – tetraazacyclo dodecane–1,4,7,10 tetraethylene phosphonic acid (Ho-DOTMP) is used fo...