A preparation of alpha-tocopherol monoglucoside (TMG) administered i.p. at a dose of 600 mg/kg immediately after whole body gamma irradiation was examined for its radioprotective efficacy towards bone marrow and peripheral blood nucleated cells. When mice received X-rays at a dose of 5,6 Gy, a marked decrease in bone marrow karyocytes and a reduction of peripheral leukocytes within the early po...

India has a diverse variety of medicinally important plants which have been claimed with beneficial therapeutic effects along with better tolerability in terms of side effects. G. asiatica also known as phalsa, a member of tiliaceae family is a small fruit crop cultivated in warmer season and is known to contain cyanidin 3glucoside, vitamin C, minerals. A brief review of work so far carried out...

objective: free radicals generated by ionizing radiation attack various cellular components such as lipids. the lung is a very radiosensitive organ and its damage is a doselimiting factor in radiotherapy treatments. melatonin (mlt), the major product of the pineal gland acts as a radioprotective agent. this study aims to investigate the radioprotective effects of mlt on malondialdehyde (mda) le...

Neurocognitive impairment is a serious adverse effect of radiation-based therapy [1]. It is well known that ionizing radiations induce oxidative stress on target tissues, mainly through the generation of reactive oxygen species (ROS) [2,3]. Spatial learning and memory are compromised after ionizing irradiation in rats using the Morris water maze test, and antioxidant-based diets are able to imp...

Background: Ionizing radiation (IR) generates reactive oxygen species (ROS), which leads to oxidative stress that often inflammatory responses in organisms. Objective: Trianthema portulacastrum L., a plant commonly growing India, is rich antioxidant phytochemicals. This responsible for scavenging free radicals and may provide radioprotective anti-inflammatory effects response ionizing radiation...

Rosmarinic acid (RA) is an ester of caffeic acid and 3, 4-dihydroxyphenyl lactic acid. It is a potent antioxidant that functions by scavenging free radicals. Here, we used a 30-day survival assay to investigate the radioprotective effects of RA. Mice were treated with RA once per day for 10 consecutive days starting at 3 days before gamma irradiation at 7.5 Gy until 7 days post irradiation. Mic...

A new stable nitronyl nitroxyl radical NIT2011 was synthesized and characterized. The radioprotective effect and pharmacokinetics profiles of NIT2011 were investigated. The results showed that when irradiation exposure dose was 6.5 Gy gama radiation, the survival rate in the irradiation-only group was 20% on 30th day. The survival rate was 70%, 80%, and 90% on 30th day when mice were pretreated...