نتایج جستجو برای: radiosensitization

تعداد نتایج: 1347  

Journal: :Cancer research 2005
Hideaki Dote David Cerna William E Burgan Kevin Camphausen Philip J Tofilon

The ability to identify tumors that are susceptible to a given molecularly targeted radiosensitizer would be of clinical benefit. Towards this end, we have investigated the effects of a representative Hsp90 inhibitor, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG), on the radiosensitivity of a panel of human tumor cell lines. 17DMAG was previously shown to enhance the radiosensi...

2014
Wan Nordiana Rahman Stéphanie Corde Naoto Yagi Siti Aishah Abdul Aziz Nathan Annabell Moshi Geso

Gold nanoparticles have been shown to enhance radiation doses delivered to biological targets due to the high absorption coefficient of gold atoms, stemming from their high atomic number (Z) and physical density. These properties significantly increase the likelihood of photoelectric effects and Compton scattering interactions. Gold nanoparticles are a novel radiosensitizing agent that can pote...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Randall J Kimple Angelina V Vaseva Adrienne D Cox Kathryn M Baerman Benjamin F Calvo Joel E Tepper Janiel M Shields Carolyn I Sartor

PURPOSE Epidermal growth factor receptor (EGFR) family members (e.g., EGFR, HER2, HER3, and HER4) are commonly overexpressed in pancreatic cancer. We investigated the effects of inhibition of EGFR/HER2 signaling on pancreatic cancer to elucidate the role(s) of EGFR/HER2 in radiosensitization and to provide evidence in support of further clinical investigations. EXPERIMENTAL DESIGN Expression ...

2016
Naoya Hayashi Yasuhiro Ogawa Kei Kubota Kazuhiro Okino Ryo Akima Shiho Morita-Tokuhiro Akira Tsuzuki Shin Yaogawa Akihito Nishioka Mitsuhiko Miyamura

We previously developed a new enzyme-targeting radiosensitization treatment named Kochi Oxydol-Radiation Therapy for Unresectable Carcinomas, Type II (KORTUC II), which contains hydrogen peroxide and sodium hyaluronate for injection into various types of tumors. For breast cancer treatment, the radiosensitization agent was injected into the tumor tissue twice a week under ultrasonographic guida...

Journal: :Endocrinology 1997
E Nishihara Y Nagayama F Mawatari K Tanaka H Namba M Niwa S Yamashita

In an attempt to develop gene therapy for thyroid carcinomas, the present studies were undertaken to evaluate in vitro and in vivo therapeutic efficacy and toxicity of herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV) treatment, a widely used prodrug/suicide gene therapy, in human thyroid carcinoma cell lines, FRO and WRO cells, using a means of retrovirus-mediated gene ...

2016
Sheng Huayin Yao Dong Zhu Chihong Qian Xiaoqian Wan Danying Feng Jianguo

BACKGROUND The expression of transglutaminase 2 (TG2) is correlated to DNA damage repair and apoptosis through the p53 pathway. The present study aimed to investigate the potential radiosensitization effect and possible mechanisms of the TG2 inhibitor KCC009 in lung cancer in vitro. MATERIAL AND METHODS A single hit multi-target model was used to plot survival curves and to calculate the sensit...

2012
Terence M. Williams Athena R. Flecha Paul Keller Ashwin Ram David Karnak Stefanie Galbán Craig J. Galbán Brian D. Ross Theodore S. Lawrence Alnawaz Rehemtulla Judith Sebolt-Leopold

There is an urgent need for the development of novel therapies to treat pancreatic cancer, which is among the most lethal of all cancers. KRAS activating mutations, which are found in >90% of pancreatic adenocarcinomas, drive tumor dependency on the Ras/MAPK and Akt signaling pathways. Radiation is currently being explored as a component of the standard treatment regimen for pancreatic cancer. ...

Journal: :Molecular cancer therapeutics 2015
Payel Chatterjee Gaurav S Choudhary Turkeyah Alswillah Xiahui Xiong Warren D Heston Cristina Magi-Galluzzi Junran Zhang Eric A Klein Alexandru Almasan

Exposure to genotoxic agents, such as ionizing radiation (IR), produces DNA damage, leading to DNA double-strand breaks (DSB); IR toxicity is augmented when the DNA repair is impaired. We reported that radiosensitization by a PARP inhibitor (PARPi) was highly prominent in prostate cancer cells expressing the TMPRSS2-ERG gene fusion protein. Here, we show that TMPRSS2-ERG blocks nonhomologous en...

2015
Jasmina Hodzic Ilse Dingjan Mariëlle JP Maas Ida H van der Meulen-Muileman Renee X de Menezes Stan Heukelom Marcel Verheij Winald R Gerritsen Albert A Geldof Baukelien van Triest Victor W van Beusechem

BACKGROUND Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying radioresistance in various cancers are poorly understood and available radiosensitizers have shown only modest clinical benefit. There is thus a need to identify new targets and drugs for more effective sensitization of cancer ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید