نتایج جستجو برای: rag2
تعداد نتایج: 856 فیلتر نتایج به سال:
The recombination activating genes, rag1 and rag2 are essential for the rearrangement of antigen receptor V, D, and J gene segments (Oettinger et al. Shinkai et al., 1992). Both genes are found in all species that are known to rearrange their antigen-specific receptors. The coding regions as well as the genomic organization of the rag locus are highly conserved throughout evolution. Rag1 and ra...
Diversity of antibodies and T cell receptors is generated by gene rearrangement dependent on RAG1 and RAG2, enzymes predicted to have been derived from a transposable element (TE) that invaded an immunoglobulin superfamily gene early in the evolution of jawed vertebrates. Now, Huang et al. report the discovery of ProtoRAG in the lower chordate Amphioxus, the long-anticipated TE related to the R...
Generation of a diverse repertoire of antigen receptor specificities via DNA recombination underpins adaptive immunity. In this issue ofGenes&Development, Carmona and colleagues (pp. 909-917) provide novel insights into the origin and function of recombination-activating gene 1 (RAG1) and RAG2, the lymphocyte-specific components of the recombinase involved in the process.
The dual specific kinase SAPK/ERK1 kinase (SEK1; mitogen-activated protein kinase kinase 4/Jun NH2 terminal kinase [ JNK] kinase) is a direct activator of stress-activated protein kinases ([SAPKs]/JNKs) in response to CD28 costimulation, CD40 signaling, or activation of the germinal center kinase. Here we show that SEK1(-/-) recombination-activating gene (RAG)2(-/-) chimeric mice have a partial...
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have emerged approximately 500 million years ago from transposon-encoded proteins. Yet no transposase sequence similar to RAG1 or RAG2 has been found. Here we show that the approximately 600-amino acid "core" region of RAG1 required for its catalytic activity is significantly ...
Published Ahead of Print 8 October 2008. 2008, 82(24):12145. DOI: 10.1128/JVI.01105-08. J. Virol. Thomas Brunner and Roberto F. Speck Erika Schlaepfer, Nadine Gehre, Stephan Regenass, Ursula Hofer, Stefan Baenziger, Mathias Heikenwalder, Immunodeficiency Virus Resistant to Rectal Transmission of Human Levels of Intestinal Engraftment and Are Cells from Human Cord Blood Show Low + Mice Transplan...
The soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), is an invasive insect pest of soybean [Glycine max (L.)Merr. (Fabaceae)] in North America, and it has led to extensive insecticide use in northern soybean-growing regions there. Host plant resistance is one potential alternative strategy for managing soybean aphid. Several Rag genes that show antibiosis and antixenosis to soybe...
The tropical Asian cyprinid genus Puntius is a major part of the ichthyofauna in Southeast Asia. Systematic status of the genus Puntius among Cyprinidae, the most prominent freshwater fish all over the world, remain to be substantiated. The molecular phylogenetic analyses derived from Recombination activating genesequences (RAG2) for 35 representative samples of Malaysian Puntius and their alli...
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