A major challenge in quantitative biological Raman spectroscopy, particularly as applied to transcutaneous Raman spectroscopy measurements, is overcoming the deleterious effects of scattering and absorption (turbidity). The Raman spectral information is distorted by multiple scattering and absorption events in the surrounding medium, thereby diminishing the prediction capability of the calibrat...

Raman spectroscopy is a non-invasive, non-destructive technique for the study of the macromolecular composition of tissues. Raman spectra were obtained from intact fresh and paraformaldehyde fixed rabbit lenses and from thin slices prepared from these lenses. In addition the Raman spectrum of an intact 82-yr-old human lens was compared with a slice of the same lens. It appeared that fixation wi...

surface-enhanced raman spectroscopy (sers) is a promising tool in the analytical science because it provides good selectivity and sensitivity without the labeling process required by fluorescence detection. this technique consists of locating the target analyte on nanometer range of roughed au-nanoparticles. the presence of the metal nanoparticles provides a tremendous enhancement to the result...

In this Letter, photoacoustic-guided Raman spectroscopy (PARS) is proposed for a fast depth-resolved Raman measurement with accurate depth localization. The approach was experimentally demonstrated to receive both photoacoustic and Raman signals from a three-layer agar phantom based on a developed synergic photoacoustic-Raman probe, showing strong depth correlation and achieving magnitude of fa...

We have performed Raman spectroscopy using a near-field scanning optical microscope. The small sample volume coupled with the light-starved nature of the Raman effect makes nano-Raman studies difficult. We present results showing near-field effects in an investigation of Rb-doped KTP. These effects include a change in selection rules due to the presence of a z-polarization component in the near...

We numerically and experimentally report the observation of slow-light spatial solitons in a Kerr medium owing to light amplification by stimulated Raman scattering. This was achieved in a CS2 nonlinear planar waveguide that possesses both a strong self-focusing nonlinearity to generate the spatial Raman soliton and a Raman susceptibility sharp enough to induce the slow-light process simultaneo...

The Raman response function and Raman nonlinear index of phosphosilicate fibers are calculated for several P2O5 concentrations. The nonlinear index of phosphosilicate fiber is estimated by using the Boling formula, and it is used to calculate the Raman fraction of the nonlinear index. On the other hand, the Raman response function of the phosphosilicate fibers is fitted to a superposition of si...

Raman spectroscopy is used to study low-wave-number (</=20 cm(-1)) acoustic vibrations of the M13 phage. A well-defined Raman line is observed at around 8.5 cm(-1). The experimental results are compared with theoretical calculations based on an elastic continuum model and appropriate Raman selection rules derived from a bond polarizability model. The observed Raman mode is shown to belong to on...

The invention of the laser in 1960 has been a very important milestone for our presentday society. This remarkable new light source not only triggered a revolution in science and technology but also gave rise to a significant improvement of the quality of our daily life. An important type of laser is the so-called Raman laser, the lasing mechanism of which is based on Stimulated Stokes Raman Sc...

To explore the effectiveness of Raman spectra to diagnose brain cancer glioblastoma multiforme (GBM), we investigated the Raman spectra of single cell from four different GBM cell lines developed from four different patients and analyzed the spectra. The Raman spectra of brain cancer (GBM) cells were similar in all these cell lines. The results indicate that Raman spectra can offer the experime...