Objective(s): Nanoparticles of iron oxide (nFe2O3) are widely used in medicine and industry and could interfere with the brain processes associated with memory. The involvement of muscarinic cholinergic receptors in the process of memory formation has been confirmed. The present study aimed to investigate the possible interference of the cholinergic muscarinic receptors of the dorsal hippocampa...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...

the µ (mu) opioid receptors, which mediate the effects of morphine, are widely distributed in brain. the purpose of this study was to design a simple expression system for rat µ-receptor in escherichia coli (bl21). in this laboratory study, rat µ-receptor cdna was isolated from pcdna3 vector using xba1 and hind3 restriction enzymes. pet-15b was digested by nco1 restriction enzyme. µ-receptor cd...

background: pioglitazone from thiazolidinediones generation, represent a new antidiabetic drugs that have been introduced in the world recently. thiazolidinediones can improve insulin resistance by activating the nuclear peroxoxisome proliferator activated receptor-γ (ppar-γ) and increasing insulin sensitivity in their receptors. insulin and its receptors are found in specific areas of cns with...

background:   astrocytes are cells within the central nervous system which are activated  in a wide spectrum of infections,  and  autoimmune and  neurodegenerative diseases.in pathologic states, they produce  inflammatory cytokines, chemokines,  and  nitric oxide (no), and sometimes  they induce apoptosis.their protease-activated receptors (pars) can be activated by proteases, e.g.thrombin and ...

Background and Aim: The purpose of the present study is to provide a basis for use Curcuma longa extract as therapeutic agent status epilepticus. Methods: effect on epilepticus in rat model was investigated. rat’s SE induced by pilocarpine evaluated through measurement seizure duration, brain oedema hippocampal oxidative stress this model. Results: In pre-treated with (400mg/kg) water content l...

  Objective(s): Brain edema is one of the most serious causes of death within the first few days after trauma brain injury (TBI). In this study we have investigated the role of Shilajit on brain edema, blood-brain barrier (BBB) permeability, intracranial pressure (ICP) and neurologic outcomes following brain trauma.   Materials and Methods: Diffuse traumatic brain trauma was indu...

Three antipeptide antibodies were prepared by immunizing rabbits with synthesized short peptides corresponding to residues 215-226, 466-479, and 478-492 predicted from the cDNA of both the human hepatoma HepG2 and rat brain glucose transporters. All three antibodies were found to precipitate quantitatively the [3H]cytochalasin B photoaffinity-labeled human erythrocyte glucose transporter. Each ...

Serotonergic 5-HT2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin brain. They have been implicated etiology many neuropsychiatric disorders serve as a target antipsychotic, antidepressant, anxiolytic drugs. Positron emission tomography imaging using suitable radioligands can be applied vivo quantification receptor densities o...