New non-steroidal estrogen-receptor antagonists, R1 128 A, B, C and D, were isolated from the cultured broth of Streptomyces sp. No. 1 128 by solvent extraction, silica gel chromatography, reverse phase chromatography and preparative HPLC. These compounds inhibited estrogen binding to its receptor. The IC50 values of R1 128 A, B, C and D for partially purified rat uterine cytosol receptor were ...

Estrogen 2- and 4-hydroxylase (ESH), a microsomal enzyme which mediates the formation of catechol estrogens, has been studied in the kidneys of castrated male Syrian hamsters, a species uniquely susceptible to induction of renal carcinomas by both steroidal and stilbene estrogens. The apparent Km for estrone was 17.0 microM, and Vmax was 0.5 pmol per mg protein per min for ESH in renal microsom...

We report on the modulatory effects of chronic subcutaneous or oral estrogen and LY117018, a selective estrogen receptor modulator, on the release of nitric oxide in rings of rat aorta studied under isometric conditions. Dilator responses to acetylcholine (ACh; 10[8] to 10[-5] M) were obtained in phenylephrine (PE; 2 microM)-contracted aorta, and constrictor dose-response curves to PE (10[-8] t...

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology (MP07)1 Sep 2021MP07-03 THE PROTECTIVE ROLE OF ESTROGEN RECEPTOR Β IN RENAL CALCIUM OXALATE FORMATION VIA REDUCING LIVER BIOSYNTHESIS AND CELL INJURY Wei Zhu, Wenbiao Ren, Chawnshang Chang, Edward M. Messing, Jean V. Joseph, Rajat Jain, David Levy, Bushinsky, Guohua Zeng, and Shuyuan Yeh ZhuWei Zhu More articles by...