The effect of several hypoglycemic sulphonylureas upon the oxidative phosphorylation of intact rat liver mitochondria was examined. Following results were obtained and discussed in relation to hypoglycemic action and uncoupling site of these drugs. 1. All hypoglycemic sulphonylurea drugs tested, i.e., tolbutamide, carbutamide, chlorpropamide, acetohexamide, glybenclamide, and glyclopyramide wer...

Biochemical studies indicate that a substantial decrease in mitochondrial ribonucleic acid (RNA) of rat liver cells occurs following parenteral administration of large doses of cortisone acetate (1). Reports have appeared indicating that carcinogens can also affect mitochondrial RNA content as well as their number (2, 3), while virus invasion of a cell alters mitochondrial morphology (4). Mitoc...