The sources of error and the optivial design of an anterior chamber infusion method for the study of rapid changes in outflow facility and intraocular pressure are discussed, with a series of definite recommendations. A saline solution for anterior chamber infusion that preserves the outflow resistance of the monkey eye has been described. Data are given showing the degree of uncertainty, cause...

1 Rosettastein Consulting UG, Freising, Germany, 2 Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, TUM-Technische Universität München, Freising, Germany, 3 Institute for Medical and Pharmaceutical Proficiency Assessment, Mainz, Germany, 4 Department of Pharmaceutical Sciences, Karl-Franzens-University Graz, Graz, Austria, 5 Molecular EXposomics, German Research Center ...

Because no suitable products are at the moment available to safely control the spread of BTV-16 in Europe, an inactivated vaccine was produced from the reference field isolate of bluetongue virus serotype 16. One group of six sheep was vaccinated subcutaneously with the inactivated vaccine twice, on days 0 and 28, whereas a second group of eight sheep was inoculated with saline solution and use...

Solutions exchange systems are responsible for the timing of drug application on patch clamp experiments. There are two basic strategies for generating a solution exchange. When slow exchanges are bearable, it is easier to perform the exchange inside the tubing system upstream of the exit port. On the other hand, fast, reproducible, exchanges are usually performed downstream of the exit port. A...

Pouched rats can detect Mycobacterium tuberculosis, which causes tuberculosis, in human sputum. Historically, a phosphate-buffered saline solution was added to sputum in the belief that doing so improved rats’ detection of M. tuberculosis, but no relevant data were available. Experiment 1 evaluated rats’ performance on samples with and without phosphate-buffered saline solution added. There was...

High throughput screening (HTS) involves using automated equipment to test a large number of samples against a defined molecular target to identify a reasonable number of active molecules in a timely fashion. Major factors which can influence priorities for the limited resources of the HTS group are projects, productivity, progress and people. The challenge to the HTS group is to provide excell...

In copper-oxides that show high-temperature superconductivity (HTS), the critical temperature (Tc) has a dome-shaped doping dependence. The cause of demise of both Tc and superfluid density ns on the overdoped side is a major puzzle. A recent study of transport and diamagnetism in a large number of overdoped La2-xSrxCuO4 (LSCO) films shows that this cannot be accounted for by disorder within th...

Recently, high-throughput screening (HTS) has become the mainstream technique for drug discovery. Compounds that are synthesized by combinatorial chemistry might be more suitable than natural products to apply to HTS, because the purification procedure is a drawback of using natural products. Nevertheless, natural products remain an extremely important source of drugs. To overcome the demerits ...

The use of hydrophilic gel contact lenses as a carrier of a non-isotonic saline solution provokes an irreversible increase in corneal thickness in the in-vivo rabbit eye. Studies on humans confirm the nature of the animal response, and it is therefore suggested that particular care should be taken when patients prepare saline solutions.

www.nursingcenter.com SUPPOSE YOU’RE caring for a patient who’s receiving 5% dextrose in 0.9% sodium chloride solution at 100 ml per hour, along with 600 mg of clindamycin every 8 hours and 80 mg of tobramycin every 8 hours. Piggybacking the antibiotics into the primary administration set is a common practice, but using a secondary set for each medication requires frequent connection and discon...