RDX is used widely as a practical secondary explosive for civilian and military applications because of its high chemical stability power. However, major shortcoming sensitivity which leads to numerous accidents by accidental initiation. One the challenges in worldwide energetic materials research design synthesis insensitive performing explosives. In this work, N,N?-bis((1H-tetrazol-5-yl)methy...

The heterochronic gene let-7 serves as a tumor suppressor microRNA by targeting various oncogenic pathways in cancer cells. Considerable evidence indicates that reduced expression of let-7 might be associated with poor clinical outcome in patients with cancer. Here, we report that the expression levels of three let-7 family members, let-7a, let-7b, and let-7g, were significantly decreased in th...

We report that hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was rapidly destroyed by sulfides in the presence of black carbon, forming nitrite and formaldehyde, rather than toxic nitrosated reduction products. Although traditionally viewed as inactive sorbents, black carbons have been noted to participate in the destruction of certain contaminants, such as azo dyes, via quinonoid groups. Howev...

Our understanding of the FERM (4.1/ezrin/radixin/moesin) protein family has been rapidly expanding in the last few years, with the result that many new physiological functions have been ascribed to these biochemically unique proteins. In the present review, we will discuss a number of new FRMD (FERM domain)-containing proteins that were initially discovered from genome sequencing but are now be...

Abstract cis-1,3,4,6-tetranitro-octahydroimidazo-[4,5-d]imidazole (BCHMX) was investigated as an energetic filler with three different plastic explosives based on matrices: C4 matrix, semtex10 matrix and EPX matrix. The original explosives, composition including RDX (1,3,5-trinitro-1,3,5-triazinane), Semtex 10 explosive PETN (pentaerythritoltetranitrate) RDX-silicone were included for compariso...

The Training Range Environmental Evaluation and Characterization System (TREECSTM) was reapplied for a previously validated model of Demolition Area 2 of the Massachusetts Military Reservation (MMR) on Cape Cod. The purpose of the exercise was to evaluate the importance of chemical-specific model input parameters, the impacts of their uncertainty, and the potential benefits of having improved e...

Second-order rate constants of the direct ozone reactions [formula: see text] and the indirect OH radical reactions [formula: see text] for nine chemicals on the US EPA's Drinking Water Contaminant Candidate List (CCL) were studied during the ozonation and ozone/hydrogen peroxide advanced oxidation process (O(3)/H(2)O(2) AOP) using batch reactors. Except for the thiocarbamate herbicides (molina...

5-Amino-4,6-dinitro-1,3-dihydroxy-benzene (6) was synthesized through the ring-opening reaction of macrocyclic compound 4 with the aid of VNS (vicarious nucleophilic substitution of hydrogen) reaction conditions. The mechanism of ring opening of macrocyclic compound 4 was studied. 5-Amino-2,4,6-trinitro-1,3-dihydroxy-benzene (8) was obtained after the nitration of 6 in KNO3 and concentrated sul...