6- mercaptopurine (6-mp) is widely used in clinic as an immunosuppressive for treatment of acute lymphocytic leukemia, crohn's disease, and ulcerative colitis with documented unpredictable hepatotoxicity. the potential molecular cytotoxic mechanisms of 6-mp against isolated rat hepatocytes were searched in this study using “accelerated cytotoxicity mechanism screening (acms)” techniques. t...

this study presents a review on advanced oxidation processes (aop) for simultaneous removal of no and so2. aop is based on using a strong oxidant such as ozone and h2o2 which is able to generate highly reactive intermediates. the pollutant will be oxidized and removed by these intermediates. in recent years, aop has been considered as an effective and attractive technology in the field of flue ...

background: psoriasis is a chronic and inflammatory dermatologic disease. inflammatory biomarkers such as c-reactive protein (crp) and erythrocyte sedimentation rate (esr) are known as immediate and delayed inflammatory biomarkers, respectively. due to the fact that anti-inflammatory drugs such as infliximab are widely used in psoriasis treatment, the aim of this study was to evaluate esr, crp ...

background: the progressive accumulation of misfolded and aggregated proteins in neurons is an accepted mechanism in aging. overproduction of reactive oxygen species (ros), referred to as oxidative stress, is currently believed to play a pivotal role in this process. lipofuscin as a histological index of aging results from cross-links between oxidized proteins and lipids. therefore, to attenuat...

background: endometriosis is defined as the existence of endometrial-like tissue outside the uterus. diagnosis of endometriosis is a challenging theme. despite the broad search for innovative laboratory tests and advances in imaging technologies, there are still no easy, non-invasive diagnostic tests available. due to inflammatory process of endometriosis, still c-reactive protein (crp) level m...

objective:  to assess whether non-surgical periodontal treatment is associated with changes in serological markers of systemic inflammation. materials and methods: thirty-five systemically healthy subjects with severe generalized periodontitis meeting the inclusion criteria participated in a four-month single blind interventional trial of which thirty-two completed the study. periodontal parame...

background: increased serum high sensitive c-reactive protein (hs-crp) in asthma and its association with disease severity has been investigated in many studies. this study aimed to determine serum hs-crp status in asthma versus healthy controls and to examine its ability in predicting asthma control. methods: serum crp was measured by elisa method using a high sensitive crp kit. severity of as...

background: reactive oxygen species (ros) are a group of free radicals that in excessive amounts have negative influence on sperm quality and function. objective: to study the effect of varicocele and its severity on the level of ros in infertile men with clinical varicocele. materials and methods: in this controlled prospective study, 42 men with clinically diagnosed left varicocele and 30 fer...

background: reactive oxygen species (ros) are a group of free radicals that in excessive amounts have negative influence on sperm quality and function. objective: we compared ros levels in seminal plasma of infertile men with this level in healthy donors. we also determined the ros level in semen of infertile men according to the etiology of infertility, and also the effect of smoking on its le...