Purpose: To formulate simvastatin orodispersible tablets with high dissolution rate and enhanced bioavailability. Methods: Simvastatin solid dispersions in βcyclodextrin, hydroxylpropyl-β-cyclodextrin, and hydroxylbutyl-β-cyclodextrin were prepared in different drug: polymer ratios by kneading and solvent evaporation methods. Compatibility was investigated by Differential scanning calorimetry (...

The aim of this study was to determine the effect of two variants of Tris-citric acid-fructose (TCF) extender containing whole hen egg yolk (TCF-HEY) and lyophilized lipoprotein fractions extracted from ostrich egg yolk (TCF-LPF(o)) on selected biological properties of cryopreserved sperm cells. Post-thaw percentage of motile sperm (MOT) was significantly higher (P < 0.05) for TCF-HEY extender ...

Smuggling and abuse of psychoactive substances has experienced an expansion with accelerated technological development over the past 20 years. The growing tendencies to use means passenger air traffic, as well improvement road air-travel infrastructure connection parts world unimaginable in past, inspired traffickers these find new routes for transportation smuggling order achieve greatest poss...

This study determines the effect of different commercial diluents on quality frozen Simmental semen. The extraction fresh semen from 3 bulls using an artificial vaginal method was performed twice a week. Fresh with motility &gt;70% further processed to one-step dilution method, and used were Andromed®, Optixcell®, Steridyl®. diluted packed into mini-straws, equilibrated, frozen, stored for test...

The ion-pair formation constant (K(MLA)(0) in mol(-1) dm(3)) for Li(B15C5)(+) with a picrate ion (Pic(-)) in water was determined by potentiometry with a K(+)-selective electrode at 25 degrees C and an ionic strength of 0, where B15C5 denotes benzo-15-crown-5 ether. Using the concentration equilibrium constants, K(MLA), estimated from this value, the extraction constants (mol(-2) dm(6) unit) of...

Laminar burning velocities and flammability limits of premixed methane/air flames in the presence of various inert gases including helium, argon, nitrogen and carbon dioxide were investigated by combined use of microgravity experiments and computations. The experiments used a short-drop free-fall laboratory facility that can eliminate the effect of buoyancy on flames and therefore enable accura...