The elderly is susceptible to infection due immunosenescence causing high cases of with significant deaths Coronavirus Disease 2019 (COVID-19) pandemic. Many studies have examined inflammatory parameters as predictors the outcome COVID-19 cases, but there has been no comparison values these between and adult groups. This study aims explain relationship parameter in group compared confirmed pati...

Immune system impairments reflected by the composition and function of circulating lymphocytes are still observed in atomic bomb survivors, and metabolic abnormalities including altered blood triglyceride and cholesterol levels have also been detected in such survivors. Based on closely related features of immune and metabolic profiles of individuals, we investigated the hypothesis that long-te...

The proportion of lymphocytes present in an individual which are reactive to the major histocompatibility (H) 1 alloantigens of another member of the same species (histocompatibility antigen-reactive cells [H-ARC]) has been shown to be unusually large. Estimates derived from studies with the graft-versus-host (GVH) reaction in vivo (1-4) and with the mixed lymphocyte interaction (MLI) in vitro ...

Lymphocytes migrate from the blood into tissue by binding to and migrating across endothelial cells. One of the endothelial cell adhesion molecules that mediate lymphocyte binding is VCAM-1. We have reported that binding to VCAM-1 activates endothelial cell NADPH oxidase for the generation of reactive oxygen species (ROS). The ROS oxidize and stimulate an increase in protein kinase C (PKC)alpha...

Styrene induces sister chromatid exchanges (SCEs) in human whole-blood lymphocyte cultures without exogenous metabolizing systems, which indicates that styrene is metabolically activated in this in vitro system. Whole-blood lymphocyte cultures from 11 male donors showed a clear increase in SCEs after a 48-hr treatment with styrene (2 mM) or with the reactive metabolite styrene 7,8-oxide (0.15 m...

BACKGROUND Slight, diffuse or focal lymphocyte proliferation is relatively common in bone marrow biopsy specimens. It may be impossible to determine whether this represents a reactive lymphocytosis or low grade non-Hodgkin lymphoma (NHL) on the basis of routine investigations alone. AIM To investigate the supplementary use of molecular biological techniques in this situation. METHODS 529 fo...

In this study, a type-2 fuzzy logic-based decision support system comprising clinical examination and blood test results that health professionals can use in addition to existing methods the diagnosis of COVID-19 has been developed. The developed consists three units. first unit produces positivity as percentage according respiratory rate, loss smell, body temperature values, second C-reactive ...

Background: Vitamin D plays a key role in the modulation of numerous immune functions against infectious agents. We aimed to explore association between serum 25‑hydroxyvitamin (25[OH] D) levels and cytokine responses, along with hematological changes, patients urinary tract infection (UTI). Materials Methods: level, cytokines (interferon [IFN]−γ, interleukin [IL]−4, IL−6, IL–10, IL−17A, tumor ...

Lymphocytes migrate from the blood across endothelial cells to reach foreign substances sequestered in peripheral lymphoid organs and inflammatory sites. To study intracellular signaling in endothelial cells during lymphocyte migration, we used murine endothelial cell lines that promote lymphocyte migration and constitutively express VCAM-1. The maximum rate of resting splenic lymphocyte migrat...

Intensive endurance exercise is known to induce lymphocyte apoptosis, which might affect immune function. Less is known about the effects of resistance exercise on apoptosis and its underlying mechanisms. In this study, subjects performed an intensive resistance test (IRT) and a moderate resistance test, and lymphocyte apoptosis, apoptosis-related parameters, and underlying mechanisms were inve...