dear editor,   the o 2 -generating enzyme nadph oxidase, plays a crucial role in host defense against microbial infection through the production of reactive oxygen species (ros). 1 the multisubunit nadph oxidase complex can be detected in vitro by the nitroblue tetrazolium test (nbt). 2 the nbt test is used for the diagnosis of chronic granulomatous disease. 3 however, several factors, such as ...

An enantioselective β-carbon amination for enals is disclosed. The nitrogen atom from a protected hydrazine with suitable electronic properties readily behaves as a nucleophile. Addition of the nitrogen nucleophile to a catalytically generated N-heterocyclic-carbene-bound α,β-unsaturated acyl azolium intermediate constructs a new carbon-nitrogen bond asymmetrically. The pyrazolidinone products ...

We employ analytical and numerical chemical evolution models to study observed trends in abundance ratios involving carbon, nitrogen, and oxygen. Several sets of published stellar yields for both intermediate-mass and massive stars are considered, and the most appropriate sets are selected through the use of analytical models. These yields are then used in the numerical models to match observed...

The past few decades have seen a massive increase in coastal eutrophication globally, leading to widespread hypoxia and anoxia, habitat degradation, alteration of food-web structure, loss of biodiversity, and increased frequency, spatial extent, and duration of harmful algal blooms. Much of this eutrophication is due to increased inputs of nitrogen to coastal oceans. Before the advent of the in...

Olanzapine was shown to be oxidized to a reactive intermediate by HOCl, which is the major oxidant produced by activated neutrophils. A mass spectrum obtained using a flow system in which the reactants were fed into a mixing chamber and the products flowed directly into a mass spectrometer revealed a reactive intermediate at m/z 311. This is 2 mass units less than the protonated molecular ion o...

We investigated the mechanical properties of nitrogen-containing graphene under tensile loading via molecular dynamics (MD) simulations. In the MD simulation, we used three types of potential functions: the second–generation reactive empirical bond order (REBO) potential for covalent C–C bonds, the Tersoff potential for covalent C–N bonds, and the Lennard–Jones potential for the interlayer inte...

Nitrogen is the fourth most abundant element in cellular biomass, and it comprises the majority of Earth's atmosphere. The interchange between inert dinitrogen gas (N2) in the extant atmosphere and 'reactive nitrogen' (those nitrogen compounds that support, or are products of, cellular metabolism and growth) is entirely controlled by microbial activities. This was not the case, however, in the ...

Intensive agricultural systems are largely responsible for the increase in global reactive nitrogen compounds, which are associated with significant environmental impacts. The nitrogen cycle in agricultural systems is complex and highly variable, which complicates characterization in environmental assessments. Appropriately representing nitrogen inputs into an ecosystem is essential to better u...