نتایج جستجو برای: receptors of interleukin
تعداد نتایج: 21189198 فیلتر نتایج به سال:
Activation of type 1 angiotensin (AT(1)) receptors causes hypertension, leading to progressive kidney injury. AT(1) receptors are expressed on immune cells, and previous studies have identified a role for immune cells in angiotensin II-dependent hypertension. We, therefore, examined the role of AT(1) receptors on immune cells in the pathogenesis of hypertension by generating bone marrow chimera...
Natural killer T (NKT) cells are important regulators of the immune system, but their trafficking machinery, including expression of chemokine receptors, has been poorly defined. Unlike other conventional T-cell populations, we show that most NKT cells express receptors for extralymphoid tissue or inflammationrelated chemokines (CCR2, CCR5, and CXCR3), while few NKT cells express lymphoid tissu...
Many studies reported that genetic variation in interleukin-1 (IL-1) receptors/Toll like receptors (TLRs) are susceptible to infectious diseases. TLRs play an important role in the innate immune response to invading pathogens. TLRs are emerging in conditions such as asthma, rheumatoid arthritis, sepsis syndrome, and systemic lupus erythromatosis, suggesting that targeting of TLRs might be usefu...
Abstract Beyond cell-cell contact, communication at a distance requires the secretion of cytokines that bind to specific receptors on responsive cells. Interleukin (IL)-9 is cytokine with pleiotropic effects not only immune cells contribute progression tumor and autoimmunity, but also structural including airway intestinal epithelial involved in development inflammatory allergic diseases. Typic...
Recent advances in our understanding of innate immunity and inflammation have direct bearing on how we understand autoimmunity, and fibrosis, and how innate immune sensors might stimulate both of these key features of several fibrotic diseases. Toll-like receptors (TLRs) are the major receptors for recognizing pathogen associated molecular patterns present on bacterial cell walls, such as LPS, ...
BACKGROUND Previous reports have shown that elevated circulating levels of cytokines and/or cytokine receptors predict adverse outcomes in patients with heart failure. However, these studies were limited by small numbers of patients and/or they were performed in a single center. In addition, these studies did not have sufficient size to address the influence of age, race, sex, and cause of hear...
A human monocytic cell line, THP-1, stimulated with 40 nM phorbol myristate acetate (PMA), differentiated to macrophage-like cells, and exhibited increased expression and release of interleukin-1 beta and expression of acetylated low density lipoprotein (ac-LDL) receptors. A selective inhibitor, MDL 29,152 (4-propyl-5-(4-quinolinyl)-2(3H)-oxazolone) was used to show that this induction required...
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