Cells respond to different kind of stress through the coordinated activation of signaling pathways such as MAPK or p53. To find which molecular mechanisms are involved, we need to understand their cell adaptation. The ribosomal protein, S6 kinase 1 (S6K1), is a common downstream target of signaling by hormonal or nutritional stress. Here, we investigated the initial contribution of S6K1/MAPK si...

The eukaryotic translation initiation factor 4B (eIF4B) plays a critical role in recruiting the 40S ribosomal subunit to the mRNA. In response to insulin, eIF4B is phosphorylated on Ser422 by S6K in a rapamycin-sensitive manner. Here we demonstrate that the p90 ribosomal protein S6 kinase (RSK) phosphorylates eIF4B on the same residue. The relative contribution of the RSK and S6K modules to the...

Kaposi’s sarcoma (KS) is a common malignancy in untreated AIDS patients that is caused by the infection of Kaposi’s sarcoma-associated herpesvirus (KSHV). KS lesions are characterized by spindle-shaped endothelial cells with infiltration of inflammatory cells and neoangiogenesis. KSHV commonly establishes default latent infection, but lytic replications occur in a small fraction of cells and pl...

BACKGROUND AND PURPOSE Hemorrhagic transformation (HT) is the most critical complication of thrombolytics in clinical trials in acute stroke. The aim of this study was to determine the rates and the predictors of HT in the Multicenter Acute Stroke Trial-Europe (MAST-E) study. METHODS We performed a post hoc analysis of MAST-E data designed to assess the safety and efficacy of streptokinase ad...

Group A streptococcal infections are sometimes followed by the inflammatory kidney disease acute post-streptococcal glomerulonephritis (APSGN). To test the importance of streptokinase in the pathogenesis of this disease, isogenic strains of the nephritis isolate NZ131, differing only in the ability to produce streptokinase of the nephritis-associated ska1 genotype, were used for infection in a ...

Reactions between purified plasminogen and streptokinase, labelled with (131)I and (125)I respectively, were investigated by polyacrylamide-gel discontinuous electrophoresis. A molecular complex consisting of both (131)I-labelled plasminogen and (125)I-labelled streptokinase migrated between plasminogen and streptokinase. This complex contained bovine plasminogen activator activity. The relativ...

OBJECTIVE (a) To develop an assay for streptokinase resistance. (b) To determine the prevalence of streptokinase resistance in patients presenting with acute myocardial infarction for the first time. (c) To determine the prevalence of streptokinase resistance in patients after exposure to streptokinase or streptococcal infection. DESIGN Open, prospective. PATIENTS 30 healthy volunteers. 40 ...

We formalize some known categorical equivalences to give a rigorous treatment of smooth representations p-adic general linear groups, as ungraded modules over quiver Hecke algebras type A. Graded variants RSK-standard are constructed for algebras. Exporting recent results from the setting, we describe an effective method construction and classification all simple quotients induced maximal hom...