نتایج جستجو برای: recombinant tissue plasminogen activator

تعداد نتایج: 1042779  

2015
Christoph A. Reichel Maximilian E. T. Hessenauer Kerstin Pflieger Markus Rehberg Sandip M. Kanse Stefan Zahler Fritz Krombach Alexander Berghaus Sebastian Strieth

Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen activator inhibitor-1 (PAI-1) have recently been implicated as individual mediators in non-fibrinolytic processes, including cell adhesion, migr...

2012
Zaid H. Al-Hamodi Riyadh Saif-Ali Ikram S. Ismail Khaled A. Ahmed Sekaran Muniandy

The plasminogen activator inhibitor-1 4G/5G and tissue plasminogen activator Alu-repeat insertion/deletion polymorphisms might be genetic determinations of increased or decreased of their plasma activities. The aim of this study was to investigate the association of plasminogen activator inhibitor-1 4G/5G and tissue plasminogen activator Alu-repeat I/D polymorphisms with metabolic syndrome para...

Journal: :Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 1990

Journal: :Stroke 2013
Mohammed Alhazzaa Mukul Sharma Dylan Blacquiere Grant Stotts Matthew Hogan Dar Dowlatshahi

BACKGROUND AND PURPOSE Thrombolysis in ischemic stroke is contraindicated in patients who have had a stroke within 3 months. However, it is unclear whether thrombolytic therapy is associated with adverse outcomes in this population. We report the characteristics and outcomes of patients treated with systemic recombinant tissue-type plasminogen activator in the context of known or unknown recent...

Journal: :Brain : a journal of neurology 2012
Maithili Sashindranath Eunice Sales Maria Daglas Roxann Freeman Andre L Samson Elisa J Cops Simone Beckham Adam Galle Catriona McLean Cristina Morganti-Kossmann Jeffrey V Rosenfeld Rime Madani Jean-Dominique Vassalli Enming J Su Daniel A Lawrence Robert L Medcalf

The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood clots. Besides its role in fibrinolysis, tissue plasmi...

1999
Wayne M. Clark

THE FOOD AND DRUG ADMINIStration (FDA) approval in June 1996 of intravenous recombinant tissue-type plasminogen activator (rt-PA) for patients with acute ischemic stroke treated within 3 hours of symptom onset marked a historic first step in treating this devastating disease. This approval was primarily based on the results of the National Institute of Neurologic Disorders (NINDS) trials (1 and...

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