نتایج جستجو برای: recombinant tissue plasminogen activator rtpa

تعداد نتایج: 1042975  

Journal: :Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010
Emily S Sena Catherine L Briscoe David W Howells Geoffrey A Donnan Peter A G Sandercock Malcolm R Macleod

Thrombolysis with recombinant tissue plasminogen activator (rtPA) improves outcome in animal models of stroke and in clinical trial, but is associated with increased intracranial hemorrhage. Here, we explore the impact of biologic and experimental design factors on efficacy and bleeding. We conducted a systematic review of studies describing the effect of tPA in thrombotic occlusion models of i...

2014
Qi Li Stephen Davis Peter Mitchell Richard Dowling Bernard Yan

The aim of our study was to compare the rapid neurological improvement after intravenous recombinant tissue-type plasminogen activator (rtPA) in patients with proximal hyperdense middle cerebral artery sign (p-HMCAS) to those without the sign and those with the distal hyperdense middle cerebral artery sign (d-HMCAS). Admission and 24 hour non-contrast CT scans of 120 patients with middle cerebr...

Journal: :Stroke 2012
Masatoshi Koga Yoshiaki Shiokawa Jyoji Nakagawara Eisuke Furui Kazumi Kimura Hiroshi Yamagami Yasushi Okada Yasuhiro Hasegawa Kazuomi Kario Satoshi Okuda Kaoru Endo Tetsuya Miyagi Masato Osaki Kazuo Minematsu Kazunori Toyoda

BACKGROUND AND PURPOSE The purpose of this study was to determine the safety and efficacy of intravenous recombinant tissue-type plasminogen activator (0.6 mg/kg alteplase) within 3 hours of stroke onset in Japanese patients outside the indications in the European license. METHODS Of the 600 patients who were treated with recombinant tissue-type plasminogen activator, 422 met the inclusion cr...

2013
Nevzat Uzuner Özcan Özdemir Gülnur Tekgöl Uzuner

Background. The relationship between the arterial recanalization after intravenous recombinant tissue plasminogen activator (rtPA) and outcomes is still uncertain. The aim of our study was to evaluate whether there is an association between the pulsatility indexes (PI) of the middle cerebral artery (MCA) measured by transcranial Doppler (TCD) after iv rtPA treatment and short- and long-term out...

Journal: :Blood 2013
Stefania Momi Michela Tantucci Maarten Van Roy Hans Ulrichts Giovanni Ricci Paolo Gresele

Thrombolytic therapy is the cornerstone of treatment of acute atherothrombotic ischemic stroke but is associated with brain hemorrhage; antiplatelet therapy has limited efficacy and is still associated with intracranial bleeding. Therefore, new antithrombotic approaches with a better efficacy/safety ratio are required. We have assessed the effect of ALX-0081, a Nanobody against the A1 domain of...

Journal: :Stroke 2011
Daniel B Herrick Wendy C Ziai Carol B Thompson Karen Lane Nichol A McBee Daniel F Hanley

BACKGROUND AND PURPOSE This is the first prospective evaluation of changes in systemic hematologic status following administration of intraventricular recombinant tissue-type plasminogen activator in patients with intraventricular hemorrhage (IVH). METHODS Laboratory data from subjects enrolled onto the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) Trials were analyzed. We ...

Journal: :Stroke 2010
Kathryn E Hitchcock Christy K Holland

BACKGROUND AND PURPOSE Ultrasound has been shown to increase recombinant tissue plasminogen activator thrombolysis through stable cavitation, or sustained bubble activity, but this mechanism needs further optimization. Use of low-frequency ultrasound in combination with microbubbles stabilized against dissolution, in the form of ultrasound contrast agents, has resulted in greater lytic efficacy...

Journal: :Stroke 2008
Joan Martí-Fàbregas Montserrat Borrell Dolores Cocho Sergi Martínez-Ramírez Mercè Martínez-Corral Jordi Fontcuberta Josep-Lluis Martí-Vilalta

BACKGROUND AND PURPOSE We evaluated the association between recombinant tissue-type plasminogen activator recanalization and change in hemostatic markers. METHODS We studied 40 patients. Recanalization was measured with transcranial Doppler. We evaluated the change in markers of coagulation (fibrinogen) and fibrinolysis (thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin) in...

Journal: :Stroke 2005
Carina Röttger Katharina Madlener Matthias Heil Tibo Gerriets Maureen Walberer Tiemo Wessels Georg Bachmann Manfred Kaps Erwin Stolz

BACKGROUND Based on a newly developed model of reversible superior sagittal sinus (SSS) thrombosis in the rat, we investigated the effect of thrombolytic and anticoagulant treatment on recanalization, brain parenchymal changes, and motor deficits. METHODS Thrombosis of the SSS was induced by topical application of ferric chloride. Occlusion was confirmed by magnetic resonance angiography (MRA...

2017
Mingjing Qiu Min Fang Xueyuan Liu

The aim of the study was to determine whether thyroid hormones level on admission in patients with ischemic stroke, treated with intravenous recombinant tissue type plasminogen activator (rtPA), was associated with symptomatic intracranial hemorrhage (sICH) and worse outcomes at 3 months.Patients with acute ischemic stroke (AIS) receiving intravenous rtPA thrombolytic treatment on our stroke un...

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