OBJECTIVE To study the relationship between semen quality and pregnancy loss in a cohort of couples attempting to conceive. DESIGN Observational prospective cohort. SETTING Not applicable. PATIENT(S) Three hundred and forty-four couples with a singleton pregnancy observed daily through 7 postconception weeks of gestation. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Association betwe...

Women with antiphospholipid syndrome (APS) and antiphospholipid antibodies (aPL) are at a high risk of recurrent spontaneous miscarriages and late pregnancy complications. The prevalence of obstetric complications in aPL positive women is about 15-20%. The APS is defined by the combination of a clinical venous or arterial thrombotic event or a pregnancy complication and the laboratory detection...

BACKGROUND Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mutations, are relatively common in the Han Chinese population. In this study we aimed to investigate the therapeutic effect of low molecular weight heparin upon women with recurre...

the measurment of various cytokines may provide a different tool for evaluation of the immune system. recent investigations have shown that the number and function of peripheral natural killer cells (nk- cells) increase during early pregnancy in women with a history of unexplained recurrent spontaneous abortions (rsa). nk-cells activity may be responsible for some cases of rsa. the objective of...

BACKGROUND Circulating microparticles are markers of cell activation associated with various prothrombotic states. As hypoxia due to uteroplacental thrombosis is considered to be one of the causes of pregnancy loss, microparticles may be associated with pregnancy loss, in addition to, or as part of, other procoagulant states such as antiphospholipid syndrome or hereditary thrombophilias. The ob...

background: normal pregnancy is thought to be dependent on th2 deviation, while recurrent pregnancy loss (rpl) and pre-eclampsia (pe) appear to be biased toward the th1 immune response. it is believed that the soluble form of cd30 (scd30) is an index of th2 immune response or modulator of th1/th2 responses. objective: the aim of this study was determination of the scd30 level in rpl and pe pati...