There is a paucity of strong evidence associated with adverse pregnancy outcomes and thrombophilia in pregnancy. These problems include both early (recurrent miscarriage) and late placental vascular-mediated problems (fetal loss, pre-eclampsia, placental abruption and intra-uterine growth restriction). Due to poor quality case-control and cohort study designs, there is often an increase in the ...

Background & Aims: Recent evidences indicate that parts of the immunoregulation system such as CD4+CD25+Tcells (Treg) and Th2 cells and Th1 cells, play very important roles in the maintenance of pregnancy. The deficiency in proper recognition of fetal alloantigen by the maternal immune system is associated with recurrent pregnancy failure. Here, we investigate the proportional changes of CD4+CD...

Recurrent pregnancy loss (RPL) is estimated to occur in 2.5% of women trying conceive. Definition RPL varies depending on used guideline. In Europe, defined as two or more lost pregnancies before 24 weeks’ gestation. Although many factors have been associated with a higher risk recurrent miscarriage, the aetiology unknown about half cases. Several related loss, such as: environmental, behaviora...

Objectives: To study the uterine artery resistance and pulsation indices during the mid luteal phase in patients with history of unexplained recurrent pregnancy loss and the effects of the nitric oxide donor isosorbid mononitrite on these indices. Study Design: A cross-section, controlled observational study. Setting: Benha University Hospital, Egypt. July 2009 to July 2010. Subjects and Method...