The present work was designed to evaluate the in vitro and in vivo anti-Candida activity of pogostone (PO), a natural product isolated from Pogostemon cablin (Blanco) Benth. PO showed potent in vitro activity against clinical Candida spp. isolates tested in this study. PO and the reference drug voriconazole (VRC) were equally effective against all the fluconazole-resistant Candida albicans stra...

BACKGROUND Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition. METHODS Data from a prospective cohort study conducted among female sex workers in Mombasa, Kenya between 1993 and 2003 were used to determine the effect of HIV-1 infection on STD susceptibility. The cohor...

There are limited data regarding the antifungal susceptibility of yeast causing vulvovaginal candidiasis, since cultures are rarely performed. Susceptibility testing was performed on vaginal yeast isolates collected from January 1998 to March 2001 from 429 patients with suspected vulvovaginal candidiasis. The charts of 84 patients with multiple positive cultures were reviewed. The 593 yeast iso...

Congenitally immunodeficient beige, athymic, and beige athymic mice whose orogastric mucosal tissues were chronically colonized and infected with a pure culture of Candida albicans were found to be resistant to naturally occurring vulvovaginal candidiasis.

Background: Candida vulvovaginitis is one of the most frequently diagnosed conditions in women’s care practices. Historically, 90% of cultured yeast species were C. albicans. However, due to a variety of interventions, the proportion of non-albicans Candida (NAC) infections appears to be increasing. We sought to estimate the current prevalence of Candida vulvovaginitis and the species-specific ...

OBJECTIVE To investigate if introital and vaginal flushing samples inoculated on chromogenic agar could increase the recovery rate and rapid identification of Candida and non-albicans species, as compared to culture of posterior vaginal fornix samples on Sabouraud agar and speciation of isolates by biochemical tests. METHODS Samples from the introitus and the posterior vaginal fornix and vagi...

ulvovaginal candidiasis (VVC) is probably the most common form of vaginal infection, although bacterial vaginosis is believed to be more frequent. 1,z Even though Candida assumes a role as a pathogen, it is an opportunistic organism causing systemic infections usually in patients who are immunosuppressed or critically ill on multiple antibiotics. However, several studies have demonstrated that ...

The widespread occurrence of vaginal candidiasis and the development of resistance against anti-fungal agents has stimulated interest in understanding the pathogenesis of this disease. The aim of our work was to characterize, in an animal model of vaginal candidiasis, the mechanisms that play a role in the induction of mucosal immunity against C. albicans and the interaction between innate and ...

33 Key points • Vulvovaginal candidiasis (VVC) covers a disease spectrum, from a single episode to chronic disease with unremitting symptoms. • The concept of chronic VVC was recently described; it is a common cause of chronic nonerosive vulvo vaginitis in women present ing at vulval disease clinics. • Evidence suggests chronic VVC is a hyper sensitivity response to commensal Candida spp. • In ...