OBJECTIVES To determine the efficacy of intra-articular corticosteroid injections for osteoarthritis of the knee and to identify numbers needed to treat. DATA SOURCES Cochrane controlled trials register, Medline (1966 to 2003), Embase (1980 to 2003), hand searches, and contact with authors. INCLUSION CRITERIA Randomised controlled trial in which the efficacy of intra-articular corticosteroi...

The idea for this special issue was shaped via numerous conversations, where we shared our passion for, and belief in, action learning. As ‘comrades in adversity’ questioned each other on the va...

PURPOSE 5-Hydroxytryptamine-3 receptor antagonists (5-HT(3) antagonists) are effective for preventing acute chemotherapy-induced emesis but the benefits of continuing administration of these agents beyond 24 hours after chemotherapy (delayed emesis) remain unclear. The purpose of this study was to provide estimates of clinical efficacy and drug acquisition cost associated with administering 5-H...

BACKGROUND Population mean changes are difficult to use in clinical practice. Responder analysis may be better, but needs validating for level of response and treatment duration. A consensus group has defined what constitutes minimal, moderate, and substantial benefit based on pain intensity and Patient Global Impression of Change scores. METHODS We obtained individual patient data from four ...

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Hypertensive response to exercise (HRE) is often documented in individuals without known cardiovascular disease. However, its impact on patient prognosis and the necessity treatment are still not clear. Objective We aimed evaluate a hypertensive test (ET) clinical outcome. Methods This was single-center retrospective ...

I examine the economic costs and benefits of granting a right of first refusal to one of two bidders in a procurement auction. This right permits the favored bidder to win a contract by matching the bid of the competing bidder. Such a right, is often observed in business interactions, especially procurement. It is commonly thought that the right of first refusal lowers the payoff to the auction...