up-regulation of cd4+cd25+cd127low/- regulatory t cells (tregs) is a new target in the treatment of asthma. human bone marrow mesenchymal stem cells can up-regulate cd4+cd25+cd127low/- regulatory t cells in vitro,  meanwhile, heme oxygenase-1 (ho-1) plays an important role in the development and maintenance of cd4+cd25+ regulatory t cells. however the mechanism has not yet been adequately under...

Motivation: Multiple models exist to describe the topology and the dynamical behavior of gene regulatory networks (GRNs). Among them, symbolic models (such as systems of ordinary differential equations) have the advantage of providing intuitive insights into the inner workings of a network so that general laws can be derived. Obtaining such models from time series data has proven to be a diffic...

At present several entirely different explanatory approaches compete to illuminate the mechanisms by which animal body plans have evolved. Their respective relevance is briefly considered here in the light of modern knowledge of genomes and the regulatory processes by which development is controlled. Just as development is a system property of the regulatory genome, causal explanation of evolut...