Three dietary carotenoids, lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ) accumulate at the central retina (macula), where they are collectively referred to as macular pigment (MP). MP's pre-receptoral absorption of blue light and consequential attenuation of the effects of chromatic aberration and light scatter are important for optimal visual function. Furthermore, antioxidant activity o...

PURPOSE To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with age-related macular degeneration (AMD). METHODS Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH)...

Age-related macular degeneration (AMD) is a debilitating, progressive eye disease faced by nearly 15% of the population aged 75 and over and is the single largest cause of legal blindness in the U.S. This condition is caused by a partial breakdown of the retinal pigment epithelium and results in damage to the macula (the portion of the retina responsible for central vision). Because it impairs ...

Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with histopathology. However, postmortem eyes from autopsy present challenges to standard OCT imaging including opaque anterior segment structures and...

purpose : to evaluate the toxic retinal effects of intravitreal bevacizumab used for the treatment of exudative age-related macular degeneration (amd) using ganzfeld electroretinography (g-erg) methods : in this prospective comparative interventional study, 23 patients with active choroidal neovascularization (cnv) associated with amd were enrolled. patients were received intravitreal injection...

I n their prospective population-based cohort study of 2389 patients in the Blue Mountains region in Australia, Liew and colleagues report on the association of long-term use of low-dose aspirin and age-related macular degeneration (AMD), the leading cause of blindness in Western countries. The principal finding is that regular aspirin use is associated with an approximately 2.5fold greater ris...

Age-related macular degeneration (AMD) leads to a marked decrease in central vision and disrupts social work activities of person. This pathology is associated with age, its clinically significant manifestations are determined the age group from 66 74 years 15% population, 75 84 - 25%, 85 older 30%. The pathogenesis this disease not fully understood. But role certain genes development age-relat...

Abstract Low vision readers depend on magnification, but magnification reduces the amount of text that can be overviewed and hampers navigation. In this study, we evaluate effects font variations letter spacing, width, boldness have low reading. We tested 20 low-vision patients with age-related macular degeneration (AMD) used Radner Reading Chart, which measures reading acuity (logRAD), maximum...

INTRODUCTION Age-related macular degeneration (AMD) related to adverse vascular changes is the most frequent cause of irreversible visual impairment in the elderly. Elevated plasma concentrations of serum homocysteine have been shown to increase the risk of vascular disease. OBJECTIVE To assess the relationship between plasma homocysteine level and age related macular degeneration. MATERIAL...