Abstract Introduction Intestinal ischemia-reperfusion is still a relevant clinical problem, especially in newborns and the elderly. In this piece of work, we check utility curcumin dexmedetomidine to overcome damage induced by reperfusion, both locally distant organs, using α-tocopherol as comparison. Methods female Wag/RijHsd rats, superior mesenteric artery was clamped for 1 h; then, animals ...

The cyclooxygenase (COX)-2 inhibitors 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5II)-furanone (DFU) (0.02-2 mg/kg) and N-[2-(cyclohexyloxy)-4-nitrofenyl]-methanesulfonamide (NS-398) (0.01-1 mg/kg), the COX-1 inhibitor 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole (SC-560) (0.05-5 mg/kg), and dexamethasone (1 mg/kg) were studied in rats challenged with intra...

When the barrier to acid back-diffusion is disrupted, there is a protective increase in gastric mucosal blood flow to help remove the back-diffusing acid. Only recently has the mechanism for calling forth this protective hyperemia been determined. The gastric mucosa and submucosa are innervated by many capsaicin-sensitive sensory nerve fibers containing vasodilator peptides. The gastric mucosal...

The aim of the present study was to assess the role of endothelin (ET) in ischemia-reperfusion (I/R)-induced mucosal injury. Mucosal permeability ((51)Cr-EDTA clearance) and tissue myeloperoxidase (MPO) activity were significantly increased after 30 min of ischemia followed by 30 min of reperfusion. The I/R-induced increases in mucosal permeability and polymorphonuclear leukocyte (PMN) infiltra...

BACKGROUND & AIMS Prophylactic injections of factor VIII reduce the incidence of bleeds and slow the development of joint damage in people with hemophilia. The aim of this study was to identify optimal person-specific prophylaxis regimens for children with hemophilia A. METHODS Analytic and numerical methods were used to identify prophylaxis regimens which maximize the time for which plasma f...

Aim: To evaluate the gastroprotective effects of Nelumbinis Rhizomatis Nodus carbon dots (NRN-CDs) on ethanol-induced gastric ulcers in rats. Materials & methods: NRN-CDs synthesized and characterized by transmission electron microscopy, ultraviolet, fluorescence Fourier transform infrared spectroscopy, x-ray photoelectron diffraction zeta potential analyzer. Their toward were evaluated mal...

Abstract Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence UC steadily increasing. Immune mechanisms are involved in pathogenesis UC, which complement shown to play a critical role inducing local responses promote tissue damage. However, function various c...

The transperineal approach is preferred to reduce prostate biopsy (PB)-related infections. Fluoroquinolones are suspended for prophylaxis of PB in the European Union; therefore, alternative antibiotics based on local resistance, or targeted prophylaxis, conjunction with povidone-iodine rectal preparation recommended transrectal PB.

Summary Hereditary angioedema (HAE) is a chronic, genetic condition which severely impacts those afflicted with intermittent recurrent vascular edema in mucosal and submucosal tissue or the dermis subcutis. These swellings adversely impact wellbeing of patients, both physically emotionally. Depending on location, patients present to doctors range disciplines, not infrequently misdiagnoses occur...