Despite numerous studies on mammalian fertilization, the mechanisms of fertilization-including the timing of acrosome reaction-remain largely unknown; more accurately described, the classical theory built upon years of layered experimental data is being challenged by recent conflicting evidence provided by gene-manipulated animals. Although in vitro fertilization remains our central research to...

Uromodulin (UMOD) gene mutation causes autosomal dominant Uromodulin-Associated Kidney Disease (UAKD), which in turn leads to end-stage renal disease. This is the first case report of a family with UAKD caused by a novel de novo mutation (E197X) in the UMOD gene. This case is a 28-year-old man with severely reduced kidney function [1]. No similar case was reported in his family history. This re...

Scientific objective: In a recent blog post Dr Andrew Thorburn 1asks why many published discoveries cannot be replicated. He summarizes examples from Dr Glenn Begley (Vice President for oncology at Amgen) that show how Amgen has been unable to reproduce many high-profile discoveries. Dr Thorburn raises the possibility that ‘sloppy science’ may partly explain our inability to measurably improve ...

Auto-immune hemolytic anemia (AIHA) has an extensive differential diagnosis though Hodgkin’s lymphoma (HL) is not always an obvious diagnosis. AIHA can precede the diagnosis of HL for several years. In adults the association of AIHA and HL is more frequent in advanced stages of HL. Warm immune hemolytic anemia is mainly controlled with steroids and chemotherapy. We report a case of a patient wi...

Having had the wonderful experience of serving as President of the American Dental Association, and in that capacity, visiting your country in 1957 and again in 1958, I met some very wonderful people. This constantly reminds me of the many responsibilites that all of us have, to do everything possible to advance the dental health of our peoples. Your dental school is a well recognized instituti...

The author describes some auscultory findings in ventricular tachycardia, which will aid the reader when he is confronted with diagnosing either supraventricular tachycardia or ventricular tachycardia. An excellent chapter discusses evaluation of the severity of hypertension based on auscultory findings. These also come from the author's studies. The author, in a chapter on functional and innoc...

The author, head of a teaching hospital surgical unit, argues that the medical curriculum must ensure that all students are exposed to a minimum of ethical discussion and decision-making. In describing his own approach he emphasises the need to show students that it is 'an intensely practical subject'. Moreover, he reminds them that moral dilemmas in medicine--perhaps a better term than medical...

We consider a dynamical system in R driven by a vector field −U ′, where U is a multi-well potential satisfying some regularity conditions. We perturb this dynamical system by a Lévy noise of small intensity and such that the heaviest tail of its Lévy measure is regularly varying. We show that the perturbed dynamical system exhibits metastable behaviour i.e. on a proper time scale it reminds of...

The holiday atmosphere abounds in marketing campaigns. present research examines how the of a brand logo influences consumers’ merchandise-related nostalgic preference. Across three studies, authors find that when consumers are exposed to logos with strong (vs. weak) atmosphere, they prefer products (Study 1). This effect occurs because generate more childhood imagery, resulting significantly c...

This paper considers the experience of miracle through writings Friedrich Nietzsche. Although he is often considered an anti-religious thinker, I argue that Nietzsche actually puts forth a positive conception because its indispensable role in creation myth. walk Nietzsche’s texts to describe his account (Wunder) and demonstrate how it reveals phenomenological perspective on by placing rooting h...