OBJECTIVE To determine the effectiveness and safety of perioperative tranexamic acid use in patients undergoing total hip or knee arthroplasty in the United States. DESIGN Retrospective cohort study; multilevel multivariable logistic regression models measured the association between tranexamic acid use in the perioperative period and outcomes. SETTING 510 US hospitals from the claims based...

BACKGROUND AND OBJECTIVES Monoclonal gammopathies frequently cause renal disease, but they may be an incidental finding. Assessment of renal pathology in the context of renal dysfunction and a monoclonal gammopathy therefore serves as a useful diagnostic tool and, in addition, provides prognostic information. There is, however, a theoretical risk of increased hemorrhagic complications from rena...

Many complications after renal transplantation can be prevented if they are detected early. Guidelines have been developed for the prevention of diseases in the general population, but there are no comprehensive guidelines for the prevention of diseases and complications after renal transplantation. Therefore, the Clinical Practice Guidelines Committee of the American Society of Transplantation...

OBJECTIVES The study investigated whether renal complications affected the efficacy and safety of tacrolimus combination therapy in patients with systemic lupus erythematosus (SLE) during a maintenance phase. METHODS Fifty-seven patients with SLE (A: 30 cases with renal complication, B: 27 cases without renal complications) were included. The presence of renal complications was defined as pro...

BACKGROUND The practice of advising patients to stop antiplatelet agents before an elective renal biopsy is widespread. The aim of this study was to compare the rate of bleeding complications in two centres that have different policies regarding the ongoing use of antiplatelet agents in patients undergoing an elective renal biopsy. Neither centre routinely checks bleeding time before renal biop...

Percutaneous renal biopsy (PRB) is a safe and effective tool in the diagnosis and management of renal disease; however, the optimal timing of observation after biopsy is not clearly established. With the use of real-time ultrasound guidance, PRB of native kidneys was performed in 750 adult patients at an academic institution by an attending nephrologist or fellow between June 1983 and June 2002...

Aims: To study the incidence of post transplant urological complications in live related kidney transplantation at our centre, and the impact of JJ ureteric stent. Patients and method: This is a reterospective review of 75 consecutive renal transplantations performed at Shaikh Zayed Post Graduate Medical Institute and National Institute of Kidney Diseases Lahore over a period of two and half ye...

The prevalence of diabetes mellitus continues to increase and is associated with significant morbidity mortality. To inform prevention strategies reduce the burden its related complications, we aimed investigate trends diabetic vascular complications-related deaths in United States. We obtained 20 years mortality data for US adults aged 18 older from National Vital Statistics System (NVSS), mul...

Neurological complications whether due to the uremic state or its treatment, contribute largely to the morbidity and mortality in patients with renal failure. Despite continuous therapeutic advances, many neurological complications of uremia, like uremic encephalopathy, atherosclerosis, neuropathy and myopathy fail to fully respond to dialysis. Moreover, dialytic therapy or kidney transplantati...

KIDNEY transplantation has improved tremendously over the past decades. After the introduction of cyclosporine (CyA), delayed graft function and surgical complications became the most important prognostic factors. Early diagnosis and management can save the grafted kidney and prevent life-threatening complications. We investigated the surgical complications in 1000 kidney transplantations at ou...