BACKGROUND The carboxy terminal cross linked telopeptide of type I collagen (ICTP) has been put forward as a marker of bone resorption. Patients with alcoholic liver disease may have osteodystrophy. AIMS To assess circulating and regional concentrations of ICTP in relation to liver dysfunction, bone metabolism, and fibrosis. METHODS In 15 patients with alcoholic cirrhosis and 20 controls, h...

The term renal osteodystrophy describes the pathological changes in bone structure in chronic kidney disease (CKD); however, this term fails to describe adequately the adverse changes in mineral and hormonal metabolism in CKD that have grave consequences for patient survival. CKD-mineral and bone disorder (CKD-MBD) is a broader, newly defined term that should be used instead of renal osteodystr...

Four selected adults with different patterns of osteodystrophy receiving regular dialysis were treated with 1-alpha-hydroxycholecalciferol (1-alpha-OHD3) 0-5-2 mug/day for 10 to 12 months. In two patients, one with osteitis fibrosa and the other with osteomalacia, significant biochemical, radiological, and histological improvements occurred, and total body calcium measured by in-vivo neutron ac...

1 Yendt ER. In: Spittel JA, ed. Clinical Medicine. Endocrinology, vol 8. Philadelphia: Harper & Row, 1983;pp 11-23. 2 Mann JB, Alterman S, Hills AG. Albright's hereditary osteodystrophy comprising 'pseudohypoparathyroidism' and 'pseudopseudohypoparathyroidism'. Ann Intern Med 1 962;56:3 15-39. 3 Drezner M, Neelon FA, Lebovitz HE, et al. 'Pseudopseudohypoparathyroidism' type II. A possible defec...

Three children with azotaemic renal osteodystrophy were treated with 1,25-dihydroxycholecalciferol (1,25(OH)2D3). All showed clinical, biochemical, and radiological improvement within 6 months of starting treatment. There were no complications. The dose of 1,25(OH)2D3 required was 0-5 microgram per day for 2 children aged 22 and 30 months, and 2 microgram per day for a 15-year-old boy. 2 of the...