The (pro)renin receptor is a newly discovered member of the brain renin-angiotensin system. To investigate the role of brain (pro)renin receptor in hypertension, adeno-associated virus-mediated (pro)renin receptor short hairpin RNA was used to knockdown (pro)renin receptor expression in the brain of nontransgenic normotensive and human renin-angiotensinogen double-transgenic hypertensive mice. ...

The importance of the renin-angiotensin system in the development and maintenance of one-kidney renal hypertension in the dog was assessed by chronically inhibiting angiotensin by continuous infusion of [Sar'-,Ala]angiotensin II or a converting enzyme inhibitor (SQ 20881). Angiotensin blockade was begun 1-2 days before renal artery constriction and continued for 6-7 days throughout the high rer...