The objective of this study was to evaluate the renoprotective effects of Uncaria Tomentosa (cat's claw) on ischemic acute kidney injury induced by renal clamping in rats. The hypoxia and hypoperfusion increase the production of reactive species already present in the inflammatory process. Results showed that the renal function evaluated by creatinine clearance, the urinary excretion of peroxid...

Title: Renoprotective RAAS inhibition does not affect the association between worse renal function and higher plasma aldosterone levels. Authors: Christina Gant ([email protected]) Gozewijn Laverman ([email protected]) Liffert Vogt ([email protected]) Maartje Slagman ([email protected]) Hiddo Heerspink ([email protected]) Femke Waanders ([email protected]) Marc Hemmelder (m.h.hemm...

Cisplatin (cis-diamine-dichloroplatinum (II), CDDP) is a prominent member of the effective broad-spectrum antitumor drugs. However, its clinical usage restricted due to serious side effects particularly nephrotoxicity. The vulnerability kidney CDDP almost certainly related primary role in excretion drug as intact and platinum containing products are excreted mainly urine. There correlation betw...