AIMS N-acetyl cysteine (NAC), an anti oxidant and a glutathione precursor, is effective in ameliorating liver injury of Tylenol overdose. There is experimental evidence that it also reduces ischemia reperfusion (I/R) injury. This clinical study was undertaken to study the effect of NAC administered in the donor operation. METHODS 22 patients were randomized to receive NAC (IV & Portal flush) ...

Chanoit G, Lee S, Xi J, Zhu M, McIntosh RA, Mueller RA, Norfleet EA, Xu Z. Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3 . Am J Physiol Heart Circ Physiol 295: H1227–H1233, 2008. First published July 25, 2008; doi:10.1152/ajpheart.00610.2008.—The purpose of this study was t...

Ischemia-reperfusion induces reactive oxygen species (ROS) formation, and ROS lead to cardiac dysfunction, in part, via the activation of the nuclear poly(ADP-ribose) polymerase (PARP, called also PARS and ADP-RT). ROS and peroxynitrite induce single-strand DNA break formation and PARP activation, resulting in NAD(+) and ATP depletion, which can lead to cell death. Although protection of cardia...

Okaya, Tomohisa, and Alex B. Lentsch. Peroxisome proliferatoractivated receptorregulates postischemic liver injury. Am J Physiol Gastrointest Liver Physiol 286: G606–G612, 2004. First published November 13, 2003; 10.1152/ajpgi.00191.2003.—Peroxisome proliferator-activated receptor(PPAR ) is a transcription factor that in some in vitro systems has been linked with downregulation of proinflammato...

background: it has been reported that the chronic oral administration of garlic homogenate protected the rat heart from in vitro ischemic reperfusion injury. however, the biological effects of garlic juice on the heart are expected to be different from oral administration of it. objective: the present study was designed to investigate the effect of garlic juice on the isolated rat heart in isch...

background: cyclosporine a (csa) is a potent immunosuppressant drug with therapeutic and toxic actions. the use of csa is limited by its toxicity. several researchers had proposed that oxidative stress could play an important role in csa-induced toxicity. arbutin has recently been shown to possess antioxidative and free radical scavenging abilities.the present study was designed to investigate ...

Background/aim: Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) a homeopathic drug that antiinflammatory antioxidant effects. This study aimed to investigate the effects of TCE on renal in rats. Materials methods: was carried out 48 Spraque-Dawley male rats, which were divided i...